129299-05-4Relevant academic research and scientific papers
Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
Han, Cheol Kyu,Ahn, Soon Kil,Choi, Nam Song,Hong, Ryung Kee,Moon, Seung Kee,Chun, Hyoung Sik,Lee, Sang Joon,Kim, Jung Woo,Hong, Chung Il,Kim, Deukjoon,Yoon, Jeong Hyeok,No, Kyoung Tai
, p. 39 - 43 (2000)
New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activi
Chemical modification of fumagillin. I. 6-O-Acyl, 6-O-sulfonyl, 6-O-alkyl, and 6-O-(N-substituted-carbamoyl)fumagillols
Marui,Itoh,Kozai,Sudo,Kishimoto
, p. 96 - 101 (2007/10/02)
The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis induced by basic fibroblast growth factor in the rat corneal micropocket assay and the growth of vascular endothelial cells in vitro. Among them, compound 2 (AGM-1470) was found to show the most potent inhibitory effect on the growth of vascular endothelial cells and was selected from this series as a candidate for further development.
