129299-51-0

Basic information

• Product Name: 6-O-(N'-benzoylallophanoyl)fumagillol
• CAS NO: 129299-51-0
• Molecular Weight: 472.538
• Mol File: 129299-51-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-O-(N'-benzoylallophanoyl)fumagillol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-O-(N'-benzoylallophanoyl)fumagillol(129299-51-0)
• EPA Substance Registry System: 6-O-(N'-benzoylallophanoyl)fumagillol(129299-51-0)

Safety Data

• Hazardous Substances Data: 129299-51-0(Hazardous Substances Data)

Upstream product

• 129299-06-5 carbamoyl fumagillol 
• 4461-33-0 benzoyl isocyanate 
• 129299-05-4 6-O-phenoxycarbonylfumagillol 
• 35903-52-7 fumagillol 

Relevant articles and documents

Chemical modification of fumagillin. I. 6-O-Acyl, 6-O-sulfonyl, 6-O-alkyl, and 6-O-(N-substituted-carbamoyl)fumagillols

The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis induced by basic fibroblast growth factor in the rat corneal micropocket assay and the growth of vascular endothelial cells in vitro. Among them, compound 2 (AGM-1470) was found to show the most potent inhibitory effect on the growth of vascular endothelial cells and was selected from this series as a candidate for further development.