129377-61-3

Upstream product

• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 
• 2862-39-7 2-(dimethylamino)ethyl bromide hydrobromide 
• 132198-53-9 2-phenyl-5H-[1,3]oxazolo[4,5-c]quinolin-4-one 
• 587884-71-7 ethyl 5-(2-aminophenyl)-2-phenyloxazole-4-carboxylate 
• 587884-70-6 ethyl 2-phenyl-5-(2-nitrophenyl)oxazole-4-carboxylate 
• 110216-61-0 4-azido-1-methyl-2(1H)quinolinone 
• 65-85-0 benzoic acid 
• 956111-58-3 3-benzoyl-4-methoxy-1-methylquinolin-2(1H)-one 

Relevant academic research and scientific papers

Synthesis of oxazolo[4,5-c]quinolones by thermolytic degradation of 4-azido-2(1H)-quinolones

4-Azido-2(1H)-quinolones 1 are thermolyzed in the presence of carboxylic acids and polyphosphoric acid to yield oxazolo[4,5-c]quinolones 3. Formation of other possible isomeric ring closure products such as oxazolo[5,4-c]quinolones 2 or isoxazolo[4,3-c]qu

Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors

Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-rel

Unambiguous structure elucidation of the reaction products of 3-acyl-4-methoxy-1-methylquinolinones with hydroxylamine via NMR spectroscopy

Reaction of 3-acyl-4-methoxy-1-methylquinolinones 2a,b with hydroxylamine has been investigated under different experimental conditions. Whereas compound 2a gives rise selectively and exclusively to the regioisomeric isoxazolo[4,5-c]- or isoxazolo[4,3-c]q

Synthesis and reactions of 3-aroyl derivatives of 4-hydroxy-2-quinolones and 4-hydroxycoumarin

3-Aroyl-4-hydroxy-2-quinolones 4 and 11 can be synthesized starting with 1 or 9 via Fries rearrangement of the corresponding esters 3 and 10, catalyzed by potassium cyanide and 18-crown-6. A one pot procedure is presented in which the esters do not need to be isolated. Reduction of the aryl ketones 4 and 11 with zinc dust leads to the benzyl derivatives 5 and 12. Reaction of the aryl ketones 4 and 11 with hydroxylamine and subsequent heating of the crude product leads via thermal Beckmann rearrangement and dehydration to oxazoloquinolones 7 and 14. 2-Aroyloxypyrido[1,2-a]pyrimidin-4-ones 17 and 20 could not be converted to the corresponding ketones by Fries rearrangement.