1294504-63-4

Basic information

• Product Name: 2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-
• Synonyms: 2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-;2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-5;(R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol
• CAS NO: 1294504-63-4
• Molecular Formula: C16H18BrFN2O2
• Molecular Weight: 369.234
• Mol File: 1294504-63-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-(1294504-63-4)
• EPA Substance Registry System: 2-Propanol, 1-[(4-aMino-2-broMo-5-fluorophenyl)aMino]-3-(phenylMethoxy)-, (2R)-(1294504-63-4)

Safety Data

• Hazardous Substances Data: 1294504-63-4(Hazardous Substances Data)

Upstream product

• 1294504-64-5 (R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol p-toluenesulfonic acid salt 
• 1342896-73-4 (R)-1-(benzyloxy)-3-(2-bromo-5-fluoro-4-nitrophenylamino)propan-2-ol 
• 2930-05-4 (S)-benzyl glycidyl ether 
• 952664-69-6 2-bromo-5-fluoro-4-nitroaniline 
• 2369-13-3 3-fluoro-4-nitroaniline 

Downstream Products

• 1294504-66-7 (R)-1-((4-amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol 
• 1294504-68-9 N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide 
• 1152311-62-0 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide 
• 1294504-67-8 (2R)-1-{5-amino-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-1-yl}-3-(benzyloxy)propan-2-ol 
• 1294504-64-5 (R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol p-toluenesulfonic acid salt 

Relevant articles and documents

SUBSTITUTED TRICYCLICS AND METHOD OF USE

The present invention provides for compounds of formula (I) wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.