129491-60-7

Upstream product

• 100-39-0 benzyl bromide 
• 52626-59-2 2,3-bis(benzylsulfanyl)maleonitrile 
• 201140-20-7 1-imino-4,7-bis(1-methylethoxy)-1H-isoindolin-3-amine 

Downstream Products

• 141272-49-3 {2,3,7,8,12,13,17,18-octakis(benzylthio)porphyrazinato}copper(II) 

Relevant academic research and scientific papers

Synthesis and optical properties of tetraazaporphyrin phosphorus(V) complexes with electron-rich heteroatoms

Tetraazaporphyrin phosphorus(V) complexes with electron-rich nitrogen and sulfur atoms at the peripheral positions were synthesized and characterized. The absorption spectra show a broad, intense band between the Soret and Q bands, which can be assigned to n → π? bands from the electron-rich heteroatoms to the electron deficient macrocyclic TAP core. Their detailed optical properties were also investigated by magnetic circular dichroism spectroscopy.

A facile and regioselective synthesis of trans-heterofunctionalized porphyrazine derivatives

New methodology was developed for the selective synthesis of regiochemically defined porphyrazines of the form M[pz(A2;B2)] (shown in Chart 1) where A and B represent peripheral functionalization attached to the β-positions of the pyrroles. Specifically, phthalonitriles or derivatives thereof with sterically bulky groups in positions 3 and 6, in particular 4,7- bis(isopropyloxy)-1,3-diiminoisoindoline (3) act as a 'trans director' when macrocyclized with heteroatom-appended maleonitriles under Linstead conditions, the result being preferential formation of the trans- M[pz(A2;B2)] pigment where A = SR, NMe2, OR, as well as R (shown in Chart 2). Linstead crossover macrocyclization of 3 with 4, 11, 15, and 18 gave pigments 10, 14, 17, and 19, respectively. These pigments were characterized by 1H NMR, 13C NMR, UV-visible spectroscopy, mass spectrometry, microanalysis, and 17 was characterized by single-crystal X-ray analysis.

Compounds, composition, and methods for photodynamic therapy

Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the formation of cytotoxic radical species in the presence of light. Significantly, the compounds, compositions, and methods of the present invention do not require the presence of oxygen in the photodynamic therapy and, as such, rely on a unimolecular mechanism for producing the radicals. The inventive compounds, compositions, and methods can be used, for example, in the treatment of cancers as well as infections caused by microorganisms such as protozoa, fungi, bacteria, and viruses.