129491-63-0

Upstream product

• 72155-45-4 Boc-L-phenylalaninal 
• 39799-78-5 1,3-dimethyl-2-imidazolinone 
• 7440-66-6 zinc 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 136740-98-2 2S,5S-Diazido-1,6-diphenyl-3,4-O-isopropylidenehexane-3R,4R-diol 
• 136740-96-0 (2R,3R,4R,5R)-3,4-O-isopropylidene-1,6-diphenyl-2,3,4,5-hexanetetraol 
• 162920-22-1 O²,O⁵-diacetyl-1,6-dichloro-O³,O⁴-isopropylidene-1,6-dideoxy-D-mannitol 
• 69-65-8 mannitol 
• 1004316-38-4 (3-benzenesulfonyl-1-benzyl-4-tert-butoxycarbonylamino-2-hydroxy-5-phenyl-pentyl)-benzyl-carbamic acid tert-butyl ester 
• 99306-88-4 (2S)-2-Benzylideneamino-3-phenylpropan-1-ol 
• 168846-63-7 (2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene 
• 158380-73-5 N-(tert-butoxycarbonyl)-N-benzyl-L-phenylalaninol 
• 158380-76-8 N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal 

Downstream Products

• 134878-07-2 (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane 
• 134878-06-1 (2S,3S,4S,5S)-2,5-diamino-1,6-diphenyl-3,4-hexanediol 
• 137649-75-3 (4S,5R,4'S,5'R)-5,5'-bis(4-benzyloxazolidin-2-one) 
• 134805-49-5 (2S,3R,4R,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane 

Relevant academic research and scientific papers

Inhibitors of retroviral proteases

The present invention relates to compounds of the formula I STR1 wherein A, Y, R2, R3, R4, R5, R6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.

Synthesis of novel C2-symmetric and pseudo C2-symmetric based diols, epoxides and dideoxy derivatives of HIV protease inhibitors

The Julia's olefination reaction between the sulfone derivative (10) and the aldehyde (13) (both obtained from L-phenylalanine) followed by debenzylation led to the formation (2S,5S,3E)-2,5-bis-[(1,1-dimethyl ethoxy)-carbonyl]amino-1,6-diphenylhex-3-ene (

Vanadium(II)- and Niobium(III)-Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to Give a C2-Symmetrical HIV Protease Inhibitor

Peptide aldehydes 15a-c are prepared without epimerization from enantiomerically pure (S)-α-amino acids (Scheme 3).Reductive pinacol homocoupling of 15a-c, induced by vanadium complex 11 or niobium complex 16 in refluxing THF, yields C2-symmetr

Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydes

Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydes A process for the preparation of optically pure symmetrical compounds of the formula I STR1 is described, in which R1, R2 and R3,

Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydes

Process for the diastereoselective reductive pinacol coupling of homochiral α-aminoaldehydes A process for the preparation of optically pure symmetrical compounds of the formula I STR1 is described in which R1, R2 and R3 a

Synthesis of a novel C2-symmetrical (2S,5S)-2,5-bis-[(1,1 -dimethylethoxy) carbonylamino]-1,6-diphenylhex-3-ene: Applications in the synthesis of potential HIV protease inhibitors

The synthesis of a novel and versatile (2S,5S)-2,5-bis-[(1,1′-dimethylethoxy)carbonylamino]-1,6-diphenylhex-3-ene (2) based on Julia's olefination strategy coupled with its application in stereoselective preparations of HIV protease inhibitors has been discussed.

Stereocontrolled Synthesis of C2-Symmetric and Pseudo-C2-Symmetric Diamino Alcohols and Diols for Use in HIV Protease Inhibitors

The stereocontrolled syntheses of dibenzyldiamino alcohol 1 and dibenzyldiamino diols 2-4, core units of potent C2-symmetric and pseudo-C2-symmetric inhibitors of HIV protease, are described, starting from phenylalanine.Stereoselecti

Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry

An efficient and stereocontrolled synthesis of various C2-symmetric HIV-1 protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.