134805-49-5

Upstream product

• 137649-69-5 (2S,3R,4R,5S)-2,5-bis<<(benzyloxy)carbonyl>amino>-3,4-dihydroxy-1,6-diphenylhexane 
• 69-65-8 mannitol 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 136740-98-2 2S,5S-Diazido-1,6-diphenyl-3,4-O-isopropylidenehexane-3R,4R-diol 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 100-58-3 phenylmagnesium bromide 
• 176168-53-9 C₁₉H₃₂N₂O₆ 
• 138328-92-4 (2S,3R,4R,5S)-2,5-Diazido-1,6-diphenyl-hexane-3,4-diol 
• 129491-63-0 (2S,3R,4R,5S)-2,5-bis[(1,1-dimethylethoxy)carbonyl]amino-1,6-diphenyl-3,4-dihydroxyhexane 

Downstream Products

• 129467-48-7 A-75925 
• 134805-50-8 (2S,3R,4R,5S)-2,5-bis(N-valinylamino)-3,4-dihydroxy-1,6-diphenylhexane 
• 134805-77-9 A 76889 

Relevant academic research and scientific papers

Double asymmetric iodoamination; synthesis of C2 symmetric and meso-amino alcohols

Alkenic diols 2 and 14 are iodocyclized providing dihydro-1,3-oxazine 3 and dihydrooxazole 15 in 90 and 93% de, respectively, which are precursors of various C2 symmetric and meso-amino alcohols.

1,4-DIAMINO-2,3-DIHYDROXYBUTANES

There are provided novel 1,4 Diamine 2,3 Dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.

Stereocontrolled Synthesis of C2-Symmetric and Pseudo-C2-Symmetric Diamino Alcohols and Diols for Use in HIV Protease Inhibitors

The stereocontrolled syntheses of dibenzyldiamino alcohol 1 and dibenzyldiamino diols 2-4, core units of potent C2-symmetric and pseudo-C2-symmetric inhibitors of HIV protease, are described, starting from phenylalanine.Stereoselecti

Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry

An efficient and stereocontrolled synthesis of various C2-symmetric HIV-1 protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.