137649-75-3Relevant academic research and scientific papers
Stereocontrolled Synthesis of C2-Symmetric and Pseudo-C2-Symmetric Diamino Alcohols and Diols for Use in HIV Protease Inhibitors
Kempf, Dale J.,Sowin, Thomas J.,Doherty, Elizabeth M.,Hannick, Steven M.,Codavoci, LynnMarie,et al.
, p. 5692 - 5700 (2007/10/02)
The stereocontrolled syntheses of dibenzyldiamino alcohol 1 and dibenzyldiamino diols 2-4, core units of potent C2-symmetric and pseudo-C2-symmetric inhibitors of HIV protease, are described, starting from phenylalanine.Stereoselecti
Pinacol Homocoupling of (S)-2- Aldehydes by 2. Synthesis of C2-Symmetric (1S,2R,3R,4S)-1,4-Diamino 2,3-Diols
Konradi, Andrei W.,Pedersen, Steven F.
, p. 28 - 32 (2007/10/02)
Six (S)-2- aldehydes 3a-f were homocoupled by 2 (1) to give C2-symmetric (1S,2R,3R,4S)-1,4-bis 2,3-diols 4a-f in good yield.High-yield conversions of the diols to biso
Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry
Ghosh, Arun K.,McKee, Scan P.,Thompson, Wayne J.
, p. 5729 - 5732 (2007/10/02)
An efficient and stereocontrolled synthesis of various C2-symmetric HIV-1 protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.
