129545-19-3

Upstream product

• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 135-02-4 ortho-anisaldehyde 
• 70122-38-2 N²-(4-methoxybenzylidene)-4-benzoyl-o-phenylenediamine 

Relevant academic research and scientific papers

Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles,15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series,47-55, were obtainedviaa reduction rea

Vanadyl Acetylacetonate-Copper (II) Trifluoro Methane Sulfonate Catalyzed Eco-friendly Synthesis of Substituted Benzimidazoles in Aqueous Media

Various substituted benzimidazoles have been successfully synthesized in aqueous medium by developing VO(acac)2–Cu(OTf)2 catalytic system. A green synthetic protocol has been created in presence of water and cetyltrimethyl ammonium bromide (CTAB) system in an organic solvent free condition. This chemoselective cyclocondensation cumoxidation process occurred in aqueous media. In this suitable method easily synthesized 2-Substituted benzimidazoles with good yields and no 1,2-disubstituted by-products were noticed. Excellent yields, environmentally benign and mild reaction condition, easy purification of the desired products are the main attractive features of this newly devised method.

Benzimidazoles from Aryl Alkyl Ketones and 2-Amino Anilines by an Iodine Catalyzed Oxidative C(CO)-C(alkyl) Bond Cleavage

Novel molecular iodine catalyzed cyclization reactions of 2-amino anilines with aryl alkyl ketones under oxidant and metal-free conditions are described. The reaction likely involves sequential C-N bond formation followed by C(CO)-C(alkyl) bond cleavage. Various 2-substituted benzimidazoles are obtained in moderate to good yields in a single step from readily available acetophenones, propiophenones, and phenylacetophenones.

Synthesis and diverse general oxidative cyclization catalysis of high-valent MoVIO2(HL) to ubiquitous heterocycles and their chiral analogues with high selectivity

The first synthesis and diverse oxidative cyclization catalysis properties of high-valent MoVI-triazole are demonstrated towards highly selective construction of benzimidazoles, benzothiazoles, isoxazolines, isoxazoles and their chiral analogue

Synthesis of glycal-based chiral benzimidazoles by VO(acac) 2-CeCl3 combo catalyst and their self-aggregated nanostructured materials

(Figure Presented) VO(acac)2-CeCl3 combo catalyst has been developed for chemoselective cyclocondensation cum oxidation under mild reaction conditions toward synthesis of a new class of optically pure compounds, 2-(2′-C-3′,4′,6′-tri-O-benzyl/methyl-glycal)-1H- benzimidazoles. It involves an operationally simple synthetic protocol efficient for the syntheses of a wide range of chiral benzimidazoles in high yields without formation of undesired 1,2-disubstituted and pseudoglycal byproducts. Vanadium(V) is found as active oxidant for the chemical processes which is investigated by UV absorption spectroscopy. Highly ordered one-dimensional low molecular mass organic nanostructured materials are fabricated by nanocrystallization of the chiral nanoscale building blocks. Theoretical calculation by the B3LYP/6-31G** level of theory of the glycal-based chiral benzimidazoles shows out of planar geometry of the 1H-anthra[1,2-d] imidazole-6,11-dione moiety, which is responsible for the strong self-aggregation to generate ultralong nanostructured materials. We have also found nice agreement between the theoretical results with the experimental observation in 2D-NOESY experiments. The photophysical property of the solid nanostructured materials is also reported. 2009 American Chemical Society.

Synthesis of some fused benzimidazole heterocyclic derivatives

Condensation of 3,4-diaminobenzophenone (1) with different aromatic aldehydes, under different conditions, gave only the corresponding mononail 2(a-d) and benzimidazole derivatives 3(a-d) without formation of the dianil. The monoanil 2(a) reacted with chloroacetyl chloride to give a mixture of 2-chloromethyl-5-benzoylbenzimidazole (4) and dibenzimidazolylethane derivative 5. The diamine 1 reacted with dimethylacetylenedicarboxylate to give the benzodiazepine-2-one derivative 6. On the other hand, 5-benzoyl-2-mercaptobenzimidazole (7) reacted with bromine, chloroacetic acid, chloroacetyl chloride, ethylbromoacetate, phenacylbromide and chloroacetone to give the corresponding benzimidazole derivatives 8-14.

Studies on formation of 1-aralkyl-2-aryl-6-benzoylbenzimidazoles from 4-benzoyl-o-phenylene diamine and aromatic aldehydes

Condensation of 4-benzyl-o-phenylenediamine (I) with aromatic aldehydes leads interestingly to 1-aralkyl-2-aryl-6- benzoylbenzimidazoles (III) besides the normal 2-aryl-5 (or 6)-benzoylbenzimidazoles (II). The intermediate has been shown to be not the dia