129622-62-4Relevant academic research and scientific papers
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Tran, Thuy-Anh,Kramer, Bryan,Shin, Young-Jun,Vallar, Pureza,Boatman, P. Douglas,Zou, Ning,Sage, Carleton R.,Gharbaoui, Tawfik,Krishnan, Ashwin,Pal, Biman,Shakya, Sagar R.,Garrido Montalban, Antonio,Adams, John W.,Ramirez, Juan,Behan, Dominic P.,Shifrina, Anna,Blackburn, Anthony,Leakakos, Tina,Shi, Yunqing,Morgan, Michael,Sadeque, Abu,Chen, Weichao,Unett, David J.,Gaidarov, Ibragim,Chen, Xiaohua,Chang, Steve,Shu, Hsin-Hui,Tung, Shiu-Feng,Semple, Graeme
, p. 913 - 927 (2017/02/19)
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in
MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
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Page/Page column 163-164, (2009/10/22)
The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to metho
