500-41-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluorodiphenylamine is used as an intermediate in organic synthesis for the production of various pharmaceuticals. Its unique structure allows it to be a key building block in the creation of a wide range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluorodiphenylamine serves as a precursor in the synthesis of various agrochemicals. Its role in this industry is crucial for the development of effective pesticides and other agricultural chemicals that protect crops and enhance agricultural productivity.
Used in Materials Science:
3-Fluorodiphenylamine is utilized as a research tool in materials science, where it aids in the exploration and development of new materials with specific properties. Its potential applications in this field are vast, including the creation of advanced polymers and other materials with tailored characteristics for specialized uses.
Used as a Reagent in Chemical Reactions:
3-Fluorodiphenylamine also functions as a reagent in various chemical reactions, facilitating specific transformations and processes in the synthesis of complex organic molecules. Its reactivity and stability make it a preferred choice in numerous chemical procedures.
Overall, 3-Fluorodiphenylamine's applications span across multiple industries, highlighting its importance and versatility in the realm of chemical research and development.

InChI:InChI=1/C12H10FN/c13-10-5-4-8-12(9-10)14-11-6-2-1-3-7-11/h1-9,14H

Upstream product

• 108-86-1 bromobenzene 
• 351-28-0 N-(3-fluorophenyl)acetamide 
• 1073-06-9 3-fluorobromobenzene 
• 103-84-4 Acetanilid 
• 77826-09-6 N-(3-fluorophenyl)-N-phenylbenzamide 
• 625-98-9 3-chlorofluorobenzene 
• 62-53-3 aniline 
• 372-19-0 meta-fluoroaniline 
• 108-90-7 chlorobenzene 
• 118-91-2 ortho-chlorobenzoic acid 
• 227805-57-4 3-fluoro-N-phenylacetanilide 
• 1338369-67-7 N-tert-butoxycarbonyl-N'-(3-fluorophenyl)-N'-phenylhydrazine 
• 914654-71-0 N-(3-fluorophenyl)-N-phenylhydrazine 
• 92491-22-0 tert-butyl 2-phenyldiazene-1-carboxylate 

Downstream Products

• 91506-59-1 N-(3-fluorophenyl)-alpha-chloroacetanilide 
• 91505-71-4 1-(3-fluorophenyl)-2(1H,3H)-indolone 
• 129622-62-4 3-fluorophenyl(phenyl)carbamic chloride 
• 1217129-27-5 C₂₂H₂₈FN 
• 1187857-70-0 4-(dimethylamino)-1-((3-fluorophenyl)(phenyl)carbamoyl)pyridinium chloride 
• 1187857-71-1 ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate 
• 1187857-72-2 ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187856-50-3 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187857-73-3 tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187857-12-0 sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187857-78-8 potassium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 

Relevant academic research and scientific papers

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF

The present invention relates to a device for emitting light. Provided are a novel mixture capable of improving stability and longevity, an organic electronic element using the same, and an electronic device thereof. (by machine translation)

PROSTACYCLIN RECEPTOR AGONIST

A compound represented by formula (I) or an isomer or a pharmaceutically acceptable salt thereof. The present invention also relates to an application of the same in preparing a drug for treating a disease related to a PGI2 receptor.

COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF

The present invention relates to a compound for allowing high luminous efficiency and low driving voltage in an element and increasing a lifespan thereof, and an organic electric element using the same, and an electronic device thereof. The compound is represented by chemical formula (1) in which Y is one of C and Si, and X^1 and X^2 are each independently the same or different, and are each selected from the group consisting of N-L^1-Ar^1, S and O.COPYRIGHT KIPO 2019

COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF

The present invention relates to a compound capable of enhancing luminous efficiency and lifetime of an element, an organic electric element using the same, and an electronic device thereof. The compound is represented by chemical formula 1. In chemical f

Reductive Molybdenum-Catalyzed Direct Amination of Boronic Acids with Nitro Compounds

The synthesis of aromatic amines is of utmost importance in a wide range of chemical contexts. We report a direct amination of boronic acids with nitro compounds to yield (hetero)aryl amines. The novel combination of a dioxomolybdenum(VI) catalyst and triphenylphosphine as inexpensive reductant has revealed to be decisive to achieve this new C?N coupling. Our methodology has proven to be scalable, air and moisture tolerant, highly chemoselective and engages both aliphatic and aromatic nitro compounds. Moreover, this general and step-economical synthesis of aromatic secondary amines showcases orthogonality to other aromatic amine syntheses as it tolerates aryl halides and carbonyl compounds.

Copper-catalyzed, ceric ammonium nitrate mediated N-arylation of amines

Cu-Catalyzed, ligand- and base-free cross-coupling of aryl boronic acids with primary and secondary amines has been reported. This ‘Chan-Evans-Lam' reaction has revealed that at room temperature, with a catalytic amount of copper(ii) acetate and ceric ammonium nitrate (CAN) as an oxidant, N-arylation can result in an effective C-N bond formation. This air stable, practical, robust protocol enables tolerance towards a variety of functional groups on both boronic acid and amine partners.

Transition-Metal-Free N-Arylation of Amines by Triarylsulfonium Triflates

A simple and efficient method for transition-metal-free N-arylation of various amines by triarylsulfonium triflates is described. Both aliphatic and aromatic amines were smoothly converted at 80 °C in the presence of tBuOK or KOH to give the corresponding mono N-arylated products in good to high yields. The molar ratios of the reactants and the choice of bases had a big effect on the reaction. When a large excess of [Ph3S][OTf] and tBuOK were employed for primary amines under the standard conditions, the bis(N-phenyl) products were predominantly formed. This method was also applicable to the synthesis of bioactive N-phenyl amino acid derivatives. The control experiments, the deuterium labelling study, and the presence of regioisomers of N-arylated products when using 4-substituted triarylsulfonium triflates suggested that the reaction might proceed through an aryne intermediate. The present protocol demonstrated that triarylsulfonium salts are versatile arylation reagents in the construction of CAr?N bonds.

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in

Effective, transition metal free and selective C-F activation under mild conditions

A simple and effective aromatic nucleophilic monosubstitution reaction for the synthesis of aromatic amines via selective C-F bond cleavage of various fluoroarenes (mono-, di-, tri-, tetra-, penta- and perfluorobenzene) with primary and secondary aromatic amines under transition metal free conditions is demonstrated. The reaction conditions were investigated thoroughly for a wide range of fluoroarene substrates bearing different numbers of fluorine atoms, and the results showed that the solvent and reaction temperature are very crucial for the successful substitution reactions. The established methods enabled the formation of nonfluorinated and partially fluorinated aromatic amines in good to excellent yields. Several functional groups were tolerated under the optimized conditions.

Efficient catalytic aryl amination of bromoarenes using 3-iminophosphine palladium(II) chloride

While pursuing the development of new hydroamination catalysts, a 3-iminophosphine palladium(II) chloride complex [(3IP)PdCl2] was synthesized that has subsequently proven to be an effective precatalyst for the aryl amination of bromoarenes. This (3IP)PdCl2 complex has been utilized in the catalytic aryl amination of both bromobenzene and bromopyridine derivatives, specifically yielding excellent activity in coupling reactions involving bromobenzene, 4-bromotoluene, and 2-bromopyridine. Using a standard set of catalytic conditions, many alkyl and aryl amines have been investigated as coupling partners in the aryl amination of bromoarenes. In general, secondary alkyl amines and ortho-substituted anilines proved to be the best substrates for this reaction, commonly giving quantitative conversion to products, while primary amines and other anilines gave only poor to moderate results. Catalytic screening data, product yields, and full characterization of isolated products are included.