23219-33-2

Usage

InChI:InChI=1/C7H6ClNO3/c8-4-2-1-3(7(11)12)5(9)6(4)10/h1-2,10H,9H2,(H,11,12)

Upstream product

• 18734-74-2 2-nitro-3-hydroxy-4-chlorobenzoic acid 
• 129634-23-7 2-(2-amino-4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 85740-98-3 4-chloro-3-methoxybenzoic acid 
• 39887-45-1 4-chloro-3-methoxybenzoyl chloride 
• 129634-21-5 2-(4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 129634-22-6 2-(2-azido-4-chloro-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 73909-16-7 2-chloro-5-methylanisole 
• 615-74-7 2-chloro-5-methylphenol 

Relevant academic research and scientific papers

Regioselective synthesis of 4-chloro-3-hydroxyanthranilic acid, a potent in vitro inhibitor of 3-hydroxyanthranilic acid oxygenase activity from rat brain

In the kynurenine metabolic pathways of tryptophan in kidney, liver and brain, 3-hydroxyanthranilic oxygenase (3-HAO, EC 1.13.11.6) catalyses the conversion of 3-hydroxyanthranilic acid to quinolinic acid, an excitatory amino acid putatively involved in brain neurodegenerative disorders. The compound 4-chloro-3-hydroxyanthranilic acid is an irreversible inhibitor of 3-HAO in the liver and the kidney. We describe here a new, unambiguous regioselective synthesis of this inhibitor and verify its activity on 3-HAO at the brain level.

SYNTHESIS OF ACTINOMYCIN ANALOGS. XV. "UNSYMMETRICAL" DERIVATIVES OF CINNABARIC ACID - AMPHOLYTES

As a result of the joint oxidative condensation of equimolar mixtures of 4-chloro-3-hydroxyanthranilic acid and its amides, containing the β-alanine and ε-aminocaproic acid residue in the amide fragment, with the hydrochloride of N-(2-dimethylaminopropyl)