129779-07-3Relevant academic research and scientific papers
Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at Their N-Terminals
Nakano, Masato,Atsuumi, Shugo,Koike, Yutaka,Tanaka, Seiichi,Funabashi, Hiroshi,et al.
, p. 505 - 508 (2007/10/02)
We describe an efficient synthesis of highly active renin inhibitors containing a sulfonemethylene isostere at their N-terminals and a hydroxyethylene isosters at their C-terminals.The stereospecific synthesis of N-terminal key intermediate, L-N-norleucine t-butyl ester is described.
