123802-54-0

Upstream product

• 2985-39-9 2-benzylmalonic acid monoethyl ester 
• 15911-73-6 L-norleucine tert-butyl ester 
• 607-81-8 diethyl 2-benzylmalonate 
• 105-53-3 diethyl malonate 
• 100-39-0 benzyl bromide 

Downstream Products

• 129831-73-8 L-N-[(2S)-2-benzyl-3-hydroxypropionyl]norleucine tert-butyl ester 
• 123878-44-4 L-N-<(2R)-2-benzyl-3-hydroxypropionyl>norleucine t-butyl ester 
• 129779-08-4 (4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide 
• 129779-07-3 (4S,5S)-5-[(S)-2-((S)-2-Benzyl-3-cyclopentanesulfonyl-propionylamino)-hexanoylamino]-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide 
• 123803-52-1 L-N-[(2R)-2-benzyl-3-(p-toluenesulfonyloxy)propionyl]norleucine tert-butyl ester 
• 123802-56-2 (S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoic acid tert-butyl ester 
• 129831-74-9 (S)-2-((S)-2-Benzyl-3-cyclopentanesulfonyl-propionylamino)-hexanoic acid tert-butyl ester 
• 123803-30-5 (S)-2-[(S)-3-Phenyl-2-(pyrimidin-2-ylsulfanylmethyl)-propionylamino]-hexanoic acid tert-butyl ester 
• 129779-06-2 (S)-2-((S)-2-Cyclopentylsulfanylmethyl-3-phenyl-propionylamino)-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

N-ACYLAMINO ACID DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS

An N-acylamino acid derivative of the formula: STR1 wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at Their N-Terminals

We describe an efficient synthesis of highly active renin inhibitors containing a sulfonemethylene isostere at their N-terminals and a hydroxyethylene isosters at their C-terminals.The stereospecific synthesis of N-terminal key intermediate, L-N-norleucine t-butyl ester is described.