131667-57-7

Basic information

• Product Name: N-Boc-3,4-dihydro-2H-pyridine
• Synonyms: 1-N-BOC-3,4-DIHYDRO-2H-PYRIDINE;3,4-DIHYDRO-2H-PYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-3,4-dihydro-2H-pyridine;tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate;REF DUPL: 1-N-Boc-3,4-dihydro-2H-pyridine;N-Boc-3,4-dihydro-2H-pyridine 97%;1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-, 1,1-dimethylethyl ester;tert-butyl 3,4-dihydro-2H-pyridine-1-carboxylate
• CAS NO: 131667-57-7
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.25
• Mol File: 131667-57-7.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 254 °C
• Flash Point: 107 °C
• Appearance: /
• Density: 1.029
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: n20/D1.477
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.56±0.20(Predicted)
• CAS DataBase Reference: N-Boc-3,4-dihydro-2H-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-3,4-dihydro-2H-pyridine(131667-57-7)
• EPA Substance Registry System: N-Boc-3,4-dihydro-2H-pyridine(131667-57-7)

Safety Data

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 45-61
• RIDADR: UN 2810 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 131667-57-7(Hazardous Substances Data)

Usage

General Description

N-Boc-3,4-dihydro-2H-pyridine is a chemical compound with the molecular formula C13H19NO2. It is also known as tert-butyl 3,4-dihydro-2H-pyridine-1-carboxylate. N-Boc-3,4-dihydro-2H-pyridine is commonly used as an intermediate in organic synthesis and pharmaceutical research. It serves as a key building block in the production of various pharmaceuticals and agrochemicals. N-Boc-3,4-dihydro-2H-pyridine is a white or off-white solid that is soluble in organic solvents such as dichloromethane and ethyl acetate. It is important to handle this compound with caution and use proper safety measures, as it may pose health hazards if not handled properly.

InChI:InChI=1/C10H17NO2/c1-10(2,3)13-9(12)11-7-5-4-6-8-11/h5,7H,4,6,8H2,1-3H3

Upstream product

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• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 
• 195964-51-3 tert-butyl 2-methoxypiperidine-1-carboxylate 
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• 116574-71-1 (±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 
• 129888-60-4 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine 
• 10387-40-3 potassium thioacetate 
• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 

Relevant articles and documents

A facile synthesis of cyclic enecarbamates using Dess-Martin periodinane

A simple and efficient synthesis of cyclic enecarbamates from ω-hydroxycarbamates via tandem oxidative cyclization-dehydration was achieved in 84% to quantitative yield using Dess-Martin periodinane in methylene chloride.

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