129922-51-6

Usage

Uses

Used in Chemical Synthesis:
1,1'-BIPHENYL, 2-[(TRIFLUOROMETHYL)THIO]is used as a building block in the synthesis of various organic compounds for its unique structural and chemical properties.
Used in Specialty Chemicals Industry:
1,1'-BIPHENYL, 2-[(TRIFLUOROMETHYL)THIO]is used as a key component in the production of specialty chemicals, where its specific properties contribute to the performance and functionality of the final products.
Used in Pharmaceutical Industry:
1,1'-BIPHENYL, 2-[(TRIFLUOROMETHYL)THIO]is used as an intermediate in the synthesis of pharmaceuticals, where its unique structure can be utilized to create new and effective drug molecules.
Used in Material Science:
1,1'-BIPHENYL, 2-[(TRIFLUOROMETHYL)THIO]is used in the development of new materials, such as polymers and coatings, where its properties can enhance the performance and durability of these materials.

Upstream product

• 2052-07-5 2-Bromobiphenyl 
• 811-68-7 silver(I) trifluoromethanethiolate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 92-52-4 biphenyl 

Downstream Products

• 129946-88-9 Umemoto's reagent 
• 129922-49-2 2-<(trifluoromethyl)sulfinyl>biphenyl 
• 160656-62-2 5-(trifluoromethyl)-5H-dibenzo[b,d]thiophenium-3-sulfonate 
• 129922-37-8 S-(trifluoromethyl)-3,7-dinitrodibenzothiophenium trifluoromethanesulfonate 
• 75070-85-8 rhodium hydrido (PEt₃)3 complex 

Relevant academic research and scientific papers

Metal-Free Direct Trifluoromethylthiolation of Aromatic Compounds Using Triptycenyl Sulfide Catalyst

Herein we report an efficient synthetic method for the electrophilic trifluoromethylthiolation of aromatic compounds. The key is to use triptycenyl sulfide (Trip-SMe) and TfOH to enhance the electrophilicity of SCF3 fragment through the formation of sulfonium intermediates. This method enables direct installation of an SCF3 group onto unactivated aromatics at room temperature, adopting a commercially available saccharin-based reagent. Preliminary DFT calculation was carried out to investigate the substitution effect on the catalytic activity.

Silver-Mediated Trifluoromethylthiolation-Iodination of Arynes

(Chemical Equation Presented). A one-pot trifluoromethylthiolation-iodination of arynes with trifluoromethylthiosilver (AgSCF3) and 1-iodophenylacetylene is described. This protocol allows rapid construction of o-trifluoromethylthiolated arene building blocks in moderate yields. These products were found to be excellent precursors for Yagupolskii-Umemoto-type electrophilic trifluoromethylation reagents.

Pd-catalyzed synthesis of Ar-SCF3 compounds under mild conditions

Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd-catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme). Copyright