129939-52-2Relevant articles and documents
Exploiting the chemistry of strained rings: Synthesis of indoles via domino reaction of aryl iodides with 2 H-azirines
Candito, David A.,Lautens, Mark
supporting information; experimental part, p. 3312 - 3315 (2010/10/19)
(Equation Presented). The highly strained 2H-azirine ring system has been the source of considerable theoretical and synthetic work. The reaction of these strained heterocycles with transition metals has been documented to give rise to ring opening and subsequent formation of varied heterocycles. An interesting domino reaction is described wherein the strained bicyclic alkene, norbornene, mediates the reaction of 2H-azirines with aryl iodides under palladium catalysis to provide indole or polycyclic dihydroimidazole heterocycles.
On the effect of ring substituents in the carbonylation of aziridines
Davoli, Paolo,Forni, Arrigo,Moretti, Irene,Prati, Fabio,Torre, Giovanni
, p. 1801 - 1812 (2007/10/03)
The effect of ring substituents on the cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to β-lactams has been investigated. A variety of aziridines with different substituents and stereochemistry has been synthesized and subjected to carbonylation. The ring expansion to β-lactam takes place in the absence of an electron-withdrawing substituent and higher yields are always obtained for cis-aziridines. Moreover, the regioselectivity of the reaction is affected by the nature of substituents at ring carbon atoms.
Regiospecific reductive cleavage of the C(2)-N bond of aziridines substituted with an electron acceptor mediated by Mg/MeOH
Pak, Chwang Siek,Kim, Tae Hoon,Ha, Sung Jin
, p. 10006 - 10010 (2007/10/03)
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