56071-96-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,2-difluoro-2-phenylacetate is used as a building block in the production of pharmaceutical drugs. Its unique chemical structure and properties make it a valuable and versatile compound in the synthesis of various pharmaceutical compounds.
Used in Agrochemical Industry:
Methyl 2,2-difluoro-2-phenylacetate is used as an intermediate in the synthesis of agrochemicals. Its unique chemical structure and properties make it a valuable and versatile compound in the production of various agrochemicals.
Used in Food and Beverage Industry:
Methyl 2,2-difluoro-2-phenylacetate is used as a flavoring agent in the food and beverage industry. Its fruity odor makes it a suitable compound for enhancing the flavor of various food and beverage products.

Upstream product

• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 40195-27-5 (1-methoxy-2-phenylvinyloxy)trimethylsilane 
• 101-41-7 benzeneacetic acid methyl ester 
• 591-50-4 iodobenzene 
• 683-98-7 methyl bromodifluoroacetate 
• 22979-35-7 Methyl phenyldiazoacetate 
• 124-38-9 carbon dioxide 
• 98-08-8 α,α,α-trifluorotoluene 
• 109872-87-9 methyl difluoroiodoacetate 

Downstream Products

• 156732-34-2 2,2,4,4-Tetrafluoro-N,N-diisopropyl-3-oxo-4-phenyl-butyramide 
• 139746-23-9 4,4-Difluoro-3-oxo-2,4-diphenyl-butyronitrile 
• 139746-18-2 4,4-difluoro-3-oxo-4-phenylbutanenitrile 
• 144156-68-3 2,2-Difluoro-1-methoxy-2-phenylethanol 
• 156732-36-4 2,2,4,4-tetrafluoro-3-hydroxy-4-phenylbutanal 
• 156732-35-3 2,2,4,4-Tetrafluoro-3-hydroxy-N,N-diisopropyl-4-phenyl-butyramide 
• 156732-38-6 ethyl 4,4,6,6-tetrafluoro-5-hydroxy-6-phenylhexanoate 
• 129973-51-9 2,2-difluoro-2-phenylethan-1-ol 
• 82302-97-4 dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate 
• 1055985-86-8 C₁₁H₁₂F₂O₄P^(1-)*Na⁽¹⁺⁾ 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 
• 1039547-75-5 C₈H₅F₂O₂^(1-)*Na⁽¹⁺⁾ 
• 785018-90-8 3,3-Difluoro-2-hydroxy-3-phenyl-propionimidic acid ethyl ester 
• 144156-71-8 Ethyl 3,3-difluoro-2-hydroxy-3-phenylpropanoate 

Relevant academic research and scientific papers

Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with α,α-Difluoroarylacetic Acids

A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.

Borosilicate Activation of (Difluoroiodo)toluene in the gem-Difluorination of Phenyldiazoacetate Derivatives

A combined experimental and computational investigation was conducted to identify a mild and effective Lewis-acidic activator for TolIF2in the gem-difluorination of diazo compounds. Computationally, borosilicate, a common constituent of laborat

Dihaloiodoarenes: α,α-dihalogenation of phenylacetate derivatives

A hypervalent iodine reagent-based α-carbonyl dihalogenation reaction is reported. Treating diazoacetate derivatives with either iodobenzene dichloride or iodotoluene difluoride results in gem-dichlorination or gem-difluorination products, respectively. The reaction is catalyzed by either Lewis acid or Lewis base activation of the aryl-λ3-iodane (ArIX2) species and proceeds rapidly and chemoselectively to the desired gem-difunctionalized products in good to excellent yield.

The effect of substituents and operating conditions on the electrochemical fluorination of alkyl phenylacetates in Et3N·4HF medium

Selective electrochemical fluorination of alkyl phenylacetates (Ph-CH2-COOR, where R is methyl, ethyl, n-propyl, n-butyl, i-propyl and sec-butyl) under galvanostatic conditions were reported in Et3N·4HF medium. Preparative electrolysis experiments were carried out both in pre-electrolysed dry Et3N·4HF and the same electrolyte medium without pre-electrolysis. Very little hydrolysed fluorinated products were obtained in pre-electrolysed medium where as significant quantities of hydrolysed products leading to fluorinated phenylacetic acid were obtained from Et3N·4HF without pre-electrolysis. Under optimum experimental conditions up to 87% selectivity of monofluoro ester could be achieved. Difluoro alkyl phenylacetate, monofluoro and difluoro phenylacetic acids were the other predominant side products obtained. The hydrolysis appears to be initiated by tautomeric transformation of proton after the initial electro oxidative formation of the cation radical. 19F as well as 1H NMR spectroscopy have been employed to identify the minor constituents formed during the electro oxidative process.

EP4 receptor agonist, compositions and methods thereof

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS

A compound of Formula (I): Formula (I) wherein: R1 is selected from hydrogen and C1-4alkyl; R2 is selected from: R4-C(R5aR5b)- , R4=C(R6)- and R7aC(R7b

EP4 receptor agonist, compositions and methods thereof

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

Selective, Electrophilic Fluorinations Using N-Fluoro-o-benzenedisulfonimide

The synthesis of N-fluoro-o-benzenedisulfonimide (NFOBS, 2) and its use as an "electrophilic" fluorinating reagent with nucleophilic substrates is described and compared with that of N-fluorobenzenesulfonimide (NFSi, 3).NFOBS (2) is prepared in three steps in 81percent overall yield from commercially available o-benzenedisulfonic acid (4) and involves treatment of o-benzenedisulfonimide (6) with dilute fluorine (10percent F2/N2).Reaction of 2 with metal enolates, silyl enol ethers, and 1,3-dicarbonyl compounds affords the corresponding α-fluoro compounds in yields up to 95percent, with good control of mono- and difluorination.Fluorination of ortho-metalated aromatic compounds was achieved in modest to good yields (10-80percent).While the reactivities of 2 and 3 are similar, better yields were observed with the former reagent in the fluorination of metal enolates, Grignard and lithium reagents, while 3 gave better results with the ortho-lithiated aromatic substrates.The available evidence suggests an SN2-type mechanism for the fluorination of nucleophilic substrates by these reagents.

Conversion of α-keto esters into β,β-difluoro-α-keto esters and corresponding acids: A simple route to a novel class of serine protease inhibitors

The preparation of a series of β,β-difluoro-α-keto esters and corresponding acids RCF2COCO2R' (R=Me, Et, i-Pr, Bn, and Ph; R'=Et and H), designed as potential inhibitors of serine proteases, is described. The standard procedure developed consists in the initial formation of an α,α- difluoro ester from an α-keto ester, followed by a simple four-step sequence involving the synthesis of hemiacetal, cyanohydrin, and α-hydroxy ester difluorinated intermediates. This method provides an easy route to β,β- difluoro-α-keto esters and corresponding acids, via 'formal' insertion of a difluoromethylene group between the R substituent and the α-carbonyl group of a generic α-keto ester.

A Catalytic Antibody Elicited by a Hapten of Tetrahedral Carbon-type

A monoclonal antibody, elicited by a α,α,α',α'-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for