129986-67-0

Basic information

• Product Name: N-METHOXY-N-METHYL(TRIPHENYL-PHOSPHORANYLIDENE)ACETAMIDE
• Synonyms: N-METHOXY-N-METHYL(TRIPHENYL-PHOSPHORANYLIDENE)ACETAMIDE;N-METHOXY-N-METHYL-2-(TRIPHENYLPHOSPHORANYLIDENE)ACETAMIDE;[N-METHOXYMETHYLAMINOCARBONYLMETHYLENE]-TRIPHENYLPHOSPHORANE;N-Methoxy-N-methyl-2-(triphenylphosphoranylidene)acetamide, 98 %;(N-methoxymethylaminocarbonylmethylene)triphenylphosphoran;N-Methoxy-N-methyl(triphenylphosphoranylidene)acetamide 98%;N-methoxy-N-methyl-2-(triphenyl-l5-phosphanylidene)acetamide
• CAS NO: 129986-67-0
• Molecular Formula: C₂₂H₂₂NO₂P
• Molecular Weight: 363.39
• Mol File: 129986-67-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 183 °C
• Boiling Point: 495.6°C at 760 mmHg
• Flash Point: 253.5°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 5.83E-10mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• BRN: 4198472
• CAS DataBase Reference: N-METHOXY-N-METHYL(TRIPHENYL-PHOSPHORANYLIDENE)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL(TRIPHENYL-PHOSPHORANYLIDENE)ACETAMIDE(129986-67-0)
• EPA Substance Registry System: N-METHOXY-N-METHYL(TRIPHENYL-PHOSPHORANYLIDENE)ACETAMIDE(129986-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 9
• Hazardous Substances Data: 129986-67-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Reactant for:Synthesis of electron-deficient alkenes via stereoselective olefination of N-sulfonyl iminesPhosphine-catalyzed asymmetric addition reactionsCysteine-catalyzed enantioselective intramolecular Rauhut-Currier reactionWittig olefinationSynthesis of aigialomycin D, a Protein Kinase inhibitor and a potential anticancer agent

InChI:InChI=1/C22H22NO2P/c1-23(25-2)22(24)18-26(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-18H,1-2H3

Upstream product

• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 603-35-0 triphenylphosphine 
• 134833-83-3 2-bromo-N-methoxy-N-methyl-acetamide 

Downstream Products

• 162253-00-1 (R)-3-Acetoxymethyl-7-[1-(methoxy-methyl-carbamoyl)-meth-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 243665-13-6 (2E)-N-methoxy-3-(4-methoxyphenyl)-N-methylprop-2-enamide 
• 345203-80-7 (2S,5R,6S)-6-[(E)-3-(Methoxy-methyl-carbamoyl)-allyl]-3,3-dimethyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 92502-26-6 (Z)-N-Methoxy-N-methyl-3-(3,4,5-trimethoxy-phenyl)-acrylamide 
• 201996-70-5 (E)-N-methoxy-N-methyl hex-2-enamide 
• 1234693-24-3 C₃₄H₄₄N₂O₆Si 
• 1234693-14-1 C₃₄H₄₂N₂O₆Si 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 170646-96-5 N-methoxy-N-methyl-3-phenylpropionamide 

Relevant articles and documents

Asymmetric synthesis of the allocolchicinoid natural product N-acetylcolchinol methyl ether (suhailamine), solid state and solution phase conformational analysis

An asymmetric synthesis of the allocolchicinoid N-acetylcolchinol methyl ether (NCME) from 3-methoxybenzaldehyde is reported. Comparison of 1H and 13C NMR spectroscopic data obtained for this sample of NCME provide further evidence f

Selective Construction of C?C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides

Herein, we report the manganese catalyzed coupling of alcohols with phosphorus ylides. The selectivity in the coupling of primary alcohols with phosphorus ylides to form carbon-carbon single (C?C) and carbon-carbon double (C=C) bonds can be controlled by the ligands. In the conversion of more challenging secondary alcohols with phosphorus ylides the selectivity towards the formation of C?C vs. C=C bonds can be controlled by the reaction conditions, namely the amount of base. The scope and limitations of the coupling reactions were thoroughly evaluated by the conversion of 21 alcohols and 15 ylides. Notably, compared to existing methods, which are based on precious metal complexes as catalysts, the present catalytic system is based on earth abundant manganese catalysts. The reaction can also be performed in a sequential one-pot reaction generating the phosphorus ylide in situ followed manganese catalyzed C?C and C=C bond formation. Mechanistic studies suggest that the C?C bond was generated via a borrowing hydrogen pathway and the C=C bond formation followed an acceptorless dehydrogenative coupling pathway. (Figure presented.).

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.