134833-83-3

Basic information

• Product Name: 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE
• Synonyms: 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE
• CAS NO: 134833-83-3
• Molecular Formula: C₄H₈BrNO₂
• Molecular Weight: 182.02
• Mol File: 134833-83-3.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 158.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.536±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE(134833-83-3)
• EPA Substance Registry System: 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE(134833-83-3)

Safety Data

• Hazardous Substances Data: 134833-83-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-methoxy-N-methyl acetamide is a chemical compound that belongs to the class of amides. It is a white solid with the molecular formula C5H9BrNO2 and a molecular weight of 186.03 g/mol. 2-BROMO-N-METHOXY-N-METHYL ACETAMIDE is commonly used in organic synthesis and pharmaceutical research as a reagent for introducing the N-methoxy-N-methylacetamide moiety into various molecules. It has been implicated in the development of new drugs and has potential applications in the treatment of various diseases. However, it is important to handle this chemical with care and follow safety and handling instructions due to its potential hazards.

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 598-21-0 2-Bromoacetyl bromide 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 216769-40-3 (R,R)-N-methoxy-N-methyl-2-(6'-tert-butyldiphenylsilanyloxymethylpyranyloxy)-acetamide 
• 129986-67-0 N-methoxy-N-methyl-2-(triphenylphosphoranylidene)acetamide 
• 166169-07-9 N-methoxy-N-methyl-2-(tritylthio)acetamide 

Relevant articles and documents

A novel synthesis of juncusol

Juncusol (7) has been prepared by a novel electrocyclization process beginning with the known β-tetralone derivative 9.

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases are responsible for a large proportion of the resistance phenotype. β-Lactamase inhibitors (BLIs) can be administered in combination with β-lactam antibiotics to negate the action of the β-lactamases, thereby restoring activity of the β-lactam. Newly developed BLIs offer some advantage over older BLIs in terms of enzymatic spectrum but are limited to the intravenous route of administration. Reported here is a novel, orally bioavailable diazabicyclooctane (DBO) β-lactamase inhibitor. This new DBO, ETX1317, contains an endocyclic carbon-carbon double bond and a fluoroacetate activating group and exhibits broad spectrum activity against class A, C, and D serine β-lactamases. The ester prodrug of ETX1317, ETX0282, is orally bioavailable and, in combination with cefpodoxime proxetil, is currently in development as an oral therapy for multidrug resistant and carbapenem-resistant Enterobacterales infections.

BETA-LACTAMASE INHIBITOR COMPOUNDS

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta- lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R2, R3, R4, R5 and R6 are described herein.

Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides

The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules.