130129-93-0Relevant academic research and scientific papers
ALYKYLENE DERIVATIVE HAVING EDG RECEPTOR ANTAGONISM
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Page/Page column 159, (2010/02/12)
PROBLEM TO BE SOLVED: To provide novel compounds having EDG (endothelial differentiation gene) receptor antagonism which are useful as active components of drugs for preventing and/or treating inflammatory diseases or the like. SOLUTION: The compounds are represented by formula (I) (wherein R1 is hydrogen or an alkyl group; R2 is hydrogen present at any substitutable position on ring C or a substituent such as a hydroxy group, a carboxy group, and a nitro group; R3 is hydrogen present at any substitutable position on ring D or a substitutent such as a hydroxy group and an aralkyloxy group; X is an alkylamino group, an amino group or the like; Y is a carboxy group, a sulfo group or a phosphono group; Z is oxygen, sulfur or the like; a ring represented by A is a 5- or 6-membered saturated or unsaturated hydrocarbon ring; and a ring represented by B is a 4- or 7-membered saturated or unsaturated hydrocarbon ring containing one -C=C- as a partial structure shown in the above formula) and include their salts and their esters.
Synthesis and Absolute Configuration of a Cytotoxic Fatty Acid Isolated from the Mushroom, Hericium erinaceum
Kuwahara, Shigefumi,Morihiro, Etsuko,Nemoto, Akira,Hiramatsu, Akira
, p. 1417 - 1419 (2007/10/02)
The naturally occurring (-)-enantiomer of a fatty acid isolated from the mushroom (Hericium erinaceum) was synthesized from (R)-(-)-benzyl glycidyl ether in 8 steps.A comparison of the specific rotation of the synthetic sample with that of the natural compound established the absolute configuration of the latter.
