130232-98-3

Usage

Uses

Used in Epoxy Resin Formulation Industry:
(R)-t-Butyl glycidyl ether is used as a reactive diluent for enhancing the processability and performance of epoxy resins. Its incorporation aids in reducing the viscosity of the resin system, allowing for improved handling and application in various industrial processes.
Used in Organic Compound Synthesis:
(R)-t-Butyl glycidyl ether serves as a valuable intermediate in the synthesis of other organic compounds. Its unique structure contributes to the formation of diverse chemical entities, expanding its utility across different chemical reactions and applications.
Used in Polymer Production:
As a starting material, (R)-t-Butyl glycidyl ether is instrumental in the production of various polymers. Its role in polymer chemistry is essential for developing new materials with specific properties tailored for specialized applications.
Safety Considerations:
While (R)-t-Butyl glycidyl ether is considered a low hazard chemical with low potential for acute toxicity, it is crucial to handle it with care. Prolonged or repeated exposure may lead to irritation of the skin, eyes, and respiratory system. Adhering to proper safety procedures is essential to mitigate any potential health risks associated with its use.

Upstream product

• 7665-72-7 t-butyl glycidyl ether 
• 67843-74-7 (S)-epichlorohydrin 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 97798-48-6 (S)-(2,3-dihydroxypropyl) phenyl sulfide 

Relevant academic research and scientific papers

Enantioselective Resolution Copolymerization of Racemic Epoxides and Anhydrides: Efficient Approach for Stereoregular Polyesters and Chiral Epoxides

Herein we report an efficient strategy for preparing isotactic polyesters and chiral epoxides via enantioselective resolution copolymerization of racemic terminal epoxides with anhydrides, mediated by enantiopure bimetallic complexes in conjunction with a nucleophilic cocatalyst. The chirality of both the axial linker and the diamine backbones of the ligand are responsible for the chiral induction of this kinetic resolution copolymerization process. The catalyst systems exhibit exceptional levels of enantioselectivity with a kinetic resolution coefficient exceeding 300 for various racemic epoxides, affording highly isotactic copolymers (selectivity factors of more than 300) with a completely alternating structure and low polydispersity index. Most of the produced isotactic polyesters are typical semicrystalline materials with melting temperatures in the range from 77 to 160 °C.

Development of a scalable synthesis of (S)-3-fluoromethyl-γ- butyrolactone, building block for Carmegliptin's Lactam moiety

Several new routes are reported for the synthesis of (S)-3-fluoromethyl- γ-butyrolactone. An asymmetric hydrogenation-based synthesis was chosen as the enabling route to produce the lactone on a 10-kg scale. A superior stereoselective route starting from (S)-tert-butyl glycidyl ether which afforded the desired lactone in three steps with ～50% overall yield was finally selected for further development and production.

A new dinuclear chiral salen complexes for asymmetric ring opening and closing reactions: Synthesis of valuable chiral intermediates

A new dinuclear chiral Co(salen) complexes bearing group 13 metals have been synthesized and characterized. The easily prepared complexes exhibited very high catalytic reactivity and enantioselectivity for the asymmetric ring opening of epoxides with H2O, chloride ions and carboxylic acids and consequently provide enantiomerically enriched terminal epoxides (>99% ee). It also catalyzes the asymmetric cyclization of ring opened product, to prepare optically pure terminal epoxides in one step. The homogeneous dinuclear chiral Co(salen) have been covalently immobilized on MCM-41. The potential benefits of heterogenization include facilitation of catalyst separation and recyclability requiring very simple techniques. The system described is very efficient.

Angiogenesis inhibitor TX-1898: Syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers

(R)- and (S)-Epichlorohydrins were used to prepare the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazoles that function as hypoxic cell radiosensitizers. The synthetic design allowed for introduction of a side chain of varying bulk th

The efficient resolution of protected diols and hydroxy aldehydes by lipases: Steric auxilliary approach and synthetic applications

1,n-Diols (n = 2-5) and 2-hydroxy aldehydes protected with a steric auxilliary are transformed by Pseudomonas lipases with high enantioselectivity, thus allowing the efficient resolution of these molecules and the synthesis of related derivatives with high optical purity.