13024-16-3Relevant articles and documents
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S.,Wiener, John J. M.,Rao, Navin L.,Pooley Deckhut, Charlotte,Barbay, J. Kent,Kreutter, Kevin D.,Bacani, Genesis M.,Wei, Jianmei,Chang, Leon,Murrey, Heather E.,Wang, Weixue,Ahn, Kay,Huber, Michael,Rex, Elizabeth,Coe, Kevin J.,Wu, Jiejun,Seierstad, Mark,Bembenek, Scott D.,Leonard, Kristi A.,Lebsack, Alec D.,Venable, Jennifer D.,Edwards, James P.
, p. 782 - 790 (2021/05/04)
Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders, BTK inhibitors have the
INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
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, (2018/06/30)
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE
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, (2017/07/06)
The present disclosure is directed to compounds of Formula (I) as Bruton's kinase inhibitors and their preparation, as well as compositions comprising compounds of Formula (I).