130250-61-2

Basic information

• Product Name: 2,N-DIMETHYL-N-METHOXYBENZAMIDE
• Synonyms: 2,N-DIMETHYL-N-METHOXYBENZAMIDE;N-Methoxy-N,2-diMethylbenzaMide
• CAS NO: 130250-61-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 130250-61-2.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 316.6°C at 760 mmHg
• Flash Point: 145.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.000407mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,N-DIMETHYL-N-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,N-DIMETHYL-N-METHOXYBENZAMIDE(130250-61-2)
• EPA Substance Registry System: 2,N-DIMETHYL-N-METHOXYBENZAMIDE(130250-61-2)

Safety Data

• Hazardous Substances Data: 130250-61-2(Hazardous Substances Data)

Usage

General Description

2,N-Dimethyl-N-methoxybenzamide is a chemical compound with the molecular formula C10H13NO2. It is a derivative of benzamide and contains two methyl groups and one methoxy group attached to the benzene ring. 2,N-DIMETHYL-N-METHOXYBENZAMIDE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities, including its role as an inhibitor of a certain enzyme involved in cancer progression. Additionally, it is known for its use in the manufacturing of dyes and other organic compounds. Overall, 2,N-dimethyl-N-methoxybenzamide plays a significant role in various chemical and pharmaceutical applications.

InChI:InChI=1/C10H13NO2/c1-8-6-4-5-7-9(8)10(12)11(2)13-3/h4-7H,1-3H3

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 42096-33-3 o-tolyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 615-37-2 ortho-methylphenyl iodide 
• 14040-11-0 tungsten hexacarbonyl 
• 95-46-5 2-methylphenyl bromide 
• 933-88-0 ortho-toluoyl chloride 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 201230-82-2 carbon monoxide 

Downstream Products

• 52922-73-3 1-(o-tolyl)-heptan-1-one 
• 43217-33-0 9,10-bis(2-methylphenyl)-anthracene 
• 100281-61-6 (4-aminophenyl)(2-methylphenyl)methanone 
• 210966-78-2 {4-[(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone 
• 529-19-1 2-Methylbenzonitrile 
• 1435892-98-0 2-(o-tolyl)-4H-quinolizin-4-one 
• 529-20-4 2-methylphenyl aldehyde 
• 175026-13-8 1-(2-methylphenyl)-2-methylprop-2-en-1-one 
• 577-16-2 2-Methylacetophenone 
• 58534-48-8 4-methyl-1-o-tolyl-pentan-1-one 
• 27810-08-8 1-(2-methylphenyl)ethanone oxime 
• 2170-09-4 N,2-dimethylbenzamide 

Relevant articles and documents

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Br?nsted Base-Catalyzed Transformation of α,β-Epoxyketones Utilizing [1,2]-Phospha-Brook Rearrangement for the Synthesis of Allylic Alcohols Having a Tetrasubstituted Alkene Moiety

A stereoselective transformation of α,β-epoxyketones into alkenylphosphates having a hydroxymethyl group on the β-carbon was established by utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis. The reaction involves the catalytic generation of an α-oxygenated carbanion located at the α-position of an epoxide moiety through the [1,2]-phospha-Brook rearrangement and the following epoxide opening. Further transformation of the alkenylphosphates by the palladium-catalyzed cross-coupling reaction with Grignard reagents provided allylic alcohols having a stereodefined all-carbon tetrasubstituted alkene moiety.

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.