130250-61-2

Usage

Uses

Used in Pharmaceutical Industry:
2,N-DIMETHYL-N-METHOXYBENZAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its integral role in creating a range of medicinal compounds.
Used in Agrochemical Industry:
2,N-DIMETHYL-N-METHOXYBENZAMIDE is utilized as an intermediate in the production of agrochemicals, contributing to the development of substances that aid in crop protection and enhancement.
Used in Cancer Research:
2,N-DIMETHYL-N-METHOXYBENZAMIDE is employed as a potential enzyme inhibitor in cancer progression, being studied for its ability to modulate biological processes that contribute to the growth and spread of cancer cells.
Used in Dye Manufacturing:
It is used as a key component in the manufacturing of dyes, playing a significant role in the production of colorants for various industries.
Used in Organic Compounds Synthesis:
2,N-DIMETHYL-N-METHOXYBENZAMIDE is used as a building block in the synthesis of other organic compounds, showcasing its versatility in organic chemistry.

InChI:InChI=1/C10H13NO2/c1-8-6-4-5-7-9(8)10(12)11(2)13-3/h4-7H,1-3H3

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 14040-11-0 tungsten hexacarbonyl 
• 95-46-5 2-methylphenyl bromide 
• 615-37-2 ortho-methylphenyl iodide 
• 13939-06-5 molybdenum hexacarbonyl 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 201230-82-2 carbon monoxide 
• 42096-33-3 o-tolyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 933-88-0 ortho-toluoyl chloride 

Downstream Products

• 142256-62-0 (2-methoxyphenyl)(2-methylphenyl)methanone 
• 39615-34-4 (2-methyl)phenyl cyclopropyl ketone 
• 529-19-1 2-Methylbenzonitrile 
• 1394949-22-4 tert-butyl 3,5-dioxo-5-(o-tolyl)pentanoate 
• 1435892-98-0 2-(o-tolyl)-4H-quinolizin-4-one 
• 90445-41-3 2-(2-Methyl-benzoyl)-benzaldehyde 
• 1227504-96-2 (S)-3-(2-methylphenyl)isobenzofuran-1(3H)-one 
• 529-20-4 2-methylphenyl aldehyde 
• 27810-08-8 1-(2-methylphenyl)ethanone oxime 
• 58534-48-8 4-methyl-1-o-tolyl-pentan-1-one 
• 577-16-2 2-Methylacetophenone 
• 52922-73-3 1-(o-tolyl)-heptan-1-one 

Relevant academic research and scientific papers

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

An α-Cyclopropanation of Carbonyl Derivatives by Oxidative Umpolung

The reactivity of iodine(III) reagents towards nucleophiles is often associated with umpolung and cationic mechanisms. Herein, we report a general process converting a range of ketone derivatives into α-cyclopropanated ketones by oxidative umpolung. Mechanistic investigation and careful characterization of side products revealed that the reaction follows an unexpected pathway and suggests the intermediacy of non-classical carbocations.

Iron-Catalyzed, Iminyl Radical-Triggered Cascade 1,5-Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five-Atom Assembling Unit

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.

Br?nsted Base-Catalyzed Transformation of α,β-Epoxyketones Utilizing [1,2]-Phospha-Brook Rearrangement for the Synthesis of Allylic Alcohols Having a Tetrasubstituted Alkene Moiety

A stereoselective transformation of α,β-epoxyketones into alkenylphosphates having a hydroxymethyl group on the β-carbon was established by utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis. The reaction involves the catalytic generation of an α-oxygenated carbanion located at the α-position of an epoxide moiety through the [1,2]-phospha-Brook rearrangement and the following epoxide opening. Further transformation of the alkenylphosphates by the palladium-catalyzed cross-coupling reaction with Grignard reagents provided allylic alcohols having a stereodefined all-carbon tetrasubstituted alkene moiety.

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.

Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent 'Ene'-Reductases

Flavin has long been known to function as a single electron reductant in biological settings, but this reactivity has rarely been observed with flavoproteins used in organic synthesis. Here we describe the discovery of an enantioselective radical dehalogenation pathway for α-bromoesters using flavin-dependent 'ene'-reductases. Mechanistic experiments support the role of flavin hydroquinone as a single electron reductant, flavin semiquinone as the hydrogen atom source, and the enzyme as the source of chirality.

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were

Mo(CO)6 as a Solid CO Source in the Synthesis of Aryl/Heteroaryl Weinreb Amides under Microwave-Enhanced Condition

The facile transformation of aryl/heteroaryl nonaflates into corresponding amides via Pd-catalyzed aminocarbonylation using Mo(CO)6 as a solid CO source under microwave-enhanced condition is reported. The method was found to be tolerant with respect to a

Light-Driven Carboxylation of o-Alkylphenyl Ketones with CO2

o-Alkylphenyl ketones undergo a C-C bond forming carboxylation reaction with CO2 simply upon irradiation with UV light or even solar light. The reaction presents a clean process exploiting light energy as the driving force for carboxylation of organic molecules with CO2.