130250-62-3Relevant articles and documents
Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes
Carminati, Daniela M.,Decaens, Jonathan,Couve-Bonnaire, Samuel,Jubault, Philippe,Fasan, Rudi
supporting information, p. 7072 - 7076 (2021/02/27)
The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat
An efficient and versatile synthesis of isoflavones from 2-methoxybenzoic acids
Lee, Jae In
, p. 1132 - 1135 (2016/07/15)
-
Copper-catalyzed synthesis of weinreb amides by oxidative amidation of alcohols
Yedage, Subhash L.,Bhanage, Bhalchandra M.
, p. 526 - 532 (2015/02/19)
A simple and efficient protocol has been developed for the oxidative amidation of alcohols to Weinreb amides using tert-butyl hydroperoxide as an oxidant and an inexpensive and air stable copper catalyst. The present protocol is advantageous as it uses commercially affordable alcohols as starting materials. The developed protocol also tolerates various substituted alcohols as starting materials to provide good to excellent yields of the desired products.