2491-31-8

Basic information

• Product Name: 1-(2-hydroxyphenyl)-2-phenylethanone
• Synonyms: 1-(2-hydroxyphenyl)-2-phenylethanone;Benzyl 2-hydroxyphenyl ketone;Benzyl o-hydroxyphenyl ketone;2-Hydroxyphenyl benzyl ketone
• CAS NO: 2491-31-8
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24388
• Mol File: 2491-31-8.mol
• Article Data: 28

Chemical Properties

• Melting Point: 55.0 to 59.0 °C
• Boiling Point: 165°C/23mmHg(lit.)
• Flash Point: 149.2°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 2.22E-05mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 1-(2-hydroxyphenyl)-2-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)-2-phenylethanone(2491-31-8)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)-2-phenylethanone(2491-31-8)

Safety Data

• Hazardous Substances Data: 2491-31-8(Hazardous Substances Data)

Usage

Preparation

Obtained by Fries rearrangement of phenyl phenylacetate,Also obtained by photo-Fries rearrangement of phenyl phenylacetate, ? in the presence of a- or b-cyclodextrin in organic solvents ; ? included in a Nafion membrane, at r.t. for 7 h (quantitative yield).? with aluminium chloride,with titanium tetrachloride in chlorobenzene at 50° for 4 h (<5%); ? with polyphosphoric acid at 100° (1%); ? with or without 20% Bleicherde at 200° for 9 h (poor yields).

InChI:InChI=1/C14H12O2/c15-13-9-5-4-8-12(13)14(16)10-11-6-2-1-3-7-11/h1-9,15H,10H2

Upstream product

• 722-01-0 phenyl phenylacetate 
• 103-82-2 phenylacetic acid 
• 108-95-2 phenol 
• 153870-76-9 1-(2-Methoxymethoxy-phenyl)-2-phenyl-ethanone 
• 7446-70-0 aluminium trichloride 
• 92151-73-0 2-phenylethynylphenol 
• 123-38-6 propionaldehyde 
• 78-84-2 isobutyraldehyde 
• 2043-61-0 cyclohexanecarbaldehyde 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 64139-02-2 3-(2-methoxy-phenyl)-3-oxo-2-phenyl-propionitrile 
• 33470-10-9 1-(2-methoxyphenyl)-2-phenylethanone 
• 119-36-8 methyl salicylate 
• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 102593-59-9 2-(2-phenylacetyl)phenyl cinnamate 
• 130406-80-3 1-(2-hydroxyphenyl)-2-phenyl-3-(hydroxyphenyl)prop-2-en-1-one 
• 130406-79-0 2-(3-hydroxyphenyl)-3-phenyl-2,3-dihydro-4H-1-benzopyran-4-one 
• 574-12-9 isoflavone 
• 79602-31-6 7-benzylsalicylidene-o-toluidine 
• 130378-80-2 2-(4-hydroxyphenyl)-3-phenyl-2,3-dihydro-4H-1-benzopyran-4-one 
• 108619-02-9 2-(2-amino-5-phenyl-thiazol-4-yl)-phenol 
• 7294-84-0 2-(2-phenylethyl)phenol 
• 29027-04-1 2-(1-imino-2-phenylethyl)phenol 
• 6005-12-5 2,3-diphenyl-4H-chromen-4-one 
• 1300584-32-0 C₁₇H₁₅NO₂ 
• 1300583-51-0 C₁₆H₁₃NO₂ 
• 1300584-27-3 (S)-2-(1-(9H-purin-6-ylamino)ethyl)-3-phenyl-4H-chromen-4-one 
• 1300583-48-5 2-((9H-purin-6-ylamino)methyl)-3-phenyl-4H-chromen-4-one 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols

A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the ketone substrate, combine in a matched manner to deliver reduction products with very high enantiomeric excess.

Ac2O-Mediated Dearylacetylative Dimerization of 2-Arylacetyl-1-naphthols: Synthesis of Naphtho[1,2-b]furan-3-ones

A novel and efficient route for the synthesis of 2-Aryl-2-naphthyl naphtho[1,2-b]furan-3-ones is described via NaH/Ac2O-mediated dearylacetylative dimerization of 2-Arylacetyl-1-naphthols in refluxing THF under open-flask conditions. A plausibl

An efficient and versatile synthesis of isoflavones from 2-methoxybenzoic acids

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