30289-28-2

Usage

Chemical Properties

clear colorless to slightly yellow liquid

InChI:InChI=1/C3H6ClNO2/c1-5(7-2)3(4)6/h1-2H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 75-44-5 phosgene 

Downstream Products

• 132960-13-5 N-methoxy-N-methyl-3-phenyl-2-propynamide 
• 153168-70-8 C₁₇H₁₅ClF₃N₃O₅S 
• 75926-79-3 N'-[2-(3-trifluoromethylphenyloxy)pyridyl-5]-N-methoxy-N-methylurea 
• 75933-20-9 N'-[2-(4-methylphenethyloxy)pyridyl-5]-N-methoxy-N-methylurea 
• 132960-12-4 N-methoxy-N,5-dimethylthiophene-2-carboxamide 
• 1207738-82-6 N-methoxy-N,4-dimethylcyclohex-1-enecarboxamide 
• 201996-70-5 (E)-N-methoxy-N-methyl hex-2-enamide 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 1207738-81-5 N-methoxy-N-methyl-2-phenylacrylamide 
• 152121-82-9 N,3‐dimethoxy‐N‐methylbenzamide 
• 145959-21-3 3-chloro-N-methoxy-N-methylbenzamide 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 

Relevant academic research and scientific papers

Cross-conjugated cyclopentenone prostaglandins synthesis of Δ7-10- chloro-15-deoxy PGA1 ethyl ester

The cationic cyclopentannelation reaction provides an unconventional but highly efficient strategy for the synthesis of unsaturated prostanoids and their analogs.

A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis

An efficient approach for the synthesis of monosubstituted aromatic compounds relying on a ring-closing metathesis followed by spontaneous 1,2-elimination is presented. The efficiency for late-stage functionalization is highlighted in various solvents (up to 920 TON). This approach is compatible with strained cycles and other multiple bonds in the substrate.

SPIRO-SULFONAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN

The disclosure is directed to compounds of Formula I (I) Pharmaceutical compositions comprising compounds of Formula I as well as methods of their use and preparation, are also described.

N-Methoxy-N-methylcyanoformamide, a Highly Reactive Reagent for the Formation of β-Keto Weinreb Amides and Unsymmetrical Ketones

A rapid and straightforward synthesis of the new and highly reactive reagent N-methoxy-N-methylcyanoformamide from trimethylsilyl cyanide and N-methoxy-N-methylcarbamoylimidazole, is reported. This reagent enables the one-pot preparation of β-carbonyl Wei

One-Pot Synthesis of O -Aryl Carbamates

A simple, versatile, one-pot procedure for the synthesis of substituted O-aryl carbamates has been developed, and a protocol is henceforth described. N-Substituted carbamoyl chloride is formed in situ and subsequently reacted with a substituted phenol, avoiding the direct manipulation of sensitive reactants. This procedure offers an economical and efficient route to many compounds of interest.

Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: Rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones

Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.

Synthesis and evaluation of carbamate prodrugs of a phenolic compound

A series of carbamates of the phenolic compound 1 were prepared and evaluated in vivo as its prodrug. Each carbamate was orally administered to rats, and plasma concentrations of the parent compound 1 were measured with the passage of time. We judged which carbamate was suitable for the prodrug of 1 from both the AUC value of 1 and absence of the carbamate in plasma. The AUC value of 1 after oral administration of 2b was approximately 40-fold higher than that for an administration of 1, and the bioconversion from 2b to 1 was excellent. As a whole, di-substituted carbamates resulted in higher plasma concentrations of 1 than did mono-substituted ones. However di-substituted carbamates were almost always detected in plasma. As a result, we found that the ethycarbamoyl derivative 2b demonstrates the best prodrug property in this series.

Palladium-catalyzed coupling reactions of N-methoxy-N-methylcarbamoyl chloride for the synthesis of N-methoxy-N-methylamides

A new synthetic method of N-methoxy-N-methylamides is developed. The palladium-catalyzed coupling reaction of N-methoxy-N-methylcarbamoyl chloride furnished N-methoxy-N-methylamide in moderate to good yield, wherein a carbonyl equivalent was appended to s