130339-76-3Relevant articles and documents
Functionalization of pyridyl ketones using deprotolithiation-: In situ zincation
Hedidi, Madani,Erb, William,Lassagne, Frédéric,Halauko, Yury S.,Ivashkevich, Oleg A.,Matulis, Vadim E.,Roisnel, Thierry,Bentabed-Ababsa, Ghenia,Mongin, Florence
, p. 63185 - 63189 (2016)
The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl2·TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest.