1303974-56-2

Basic information

• Product Name: ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate
• Synonyms: ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate
• CAS NO: 1303974-56-2
• Molecular Weight: 283.318
• Mol File: 1303974-56-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate(1303974-56-2)
• EPA Substance Registry System: ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate(1303974-56-2)

Safety Data

• Hazardous Substances Data: 1303974-56-2(Hazardous Substances Data)

Usage

General Description

Ethyl 4,4-difluoro-1-(phenylmethyl)-3-piperidinecarboxylate is a chemical compound used in the synthesis and development of pharmaceuticals. It belongs to the class of piperidinecarboxylate compounds and contains a phenylmethyl group, as well as two fluorine atoms. This chemical is commonly used in medicinal chemistry research and drug discovery efforts, where it can be employed as a building block or intermediate in the production of various pharmaceutical products. Its specific structure and properties make it valuable for the development of potential drug candidates, particularly within the central nervous system and psychiatric disorder areas. Moreover, this compound may also have applications in other fields, such as agrochemicals or materials science, due to its unique molecular structure.

Upstream product

• 41276-30-6 C₉H₁₄O₃NC₆H₅ 

Downstream Products

• 1303973-24-1 1,1-dimethylethyl 4,4-difluoro-3-(hydroxymethyl)-1-piperidinecarboxylate 
• 1303973-25-2 [4,4-difluoro-1-(phenylmethyl)-3-piperidinyl]methanol 
• 1303974-65-3 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-3-carboxylic acid 

Relevant articles and documents

Semi-Industrial Fluorination of β-Keto Esters with SF 4: Safety vs Efficacy

The possibility of deoxofluorination of β-keto esters using SF 4 was investigated. The scope and limitation of the reaction were determined. The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chemistry, were synthesized on multigram scale. The safety of SF 4 use was discussed. The described method does not improve upon the safety of using SF 4, but practical recommendations for working with the reagent are proposed. Despite the hazards of using toxic SF 4, a significant increase of efficacy in the synthesis of medicinal-chemistry-relevant building blocks, based on the reaction, in comparison with earlier described approaches is shown.

PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS

A compound of formula (I) or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.