1304385-08-7Relevant academic research and scientific papers
Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions
Tamura, Toshiyuki,Moriyama, Katsuhiko,Togo, Hideo
, p. 2023 - 2029 (2015)
Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.
ETHYNE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Page/Page column 81, (2012/03/27)
invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them
New compounds, pharmaceutical compositions and uses thereof
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Page/Page column 34, (2012/09/05)
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
New compounds, pharmaceutical compositions and uses thereof
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Page/Page column 50, (2012/09/05)
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
