130468-02-9

Upstream product

• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 77745-22-3 exo-cis-5,6-Dihydroxy-2-azabicyclo<2.2.1>heptan-3-one 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 116856-56-5 3-(4-{2-[6-Amino-9-((1R,2S,3R,4S)-4-ethylcarbamoyl-2,3-dihydroxy-cyclopentyl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid tert-butyl ester 
• 116909-62-7 3-(4-{2-[6-Amino-9-((1R,2S,3R,4S)-4-ethylcarbamoyl-2,3-dihydroxy-cyclopentyl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid; hydrochloride 
• 116856-30-5 (1S,2R,3S,4R)-4-(6-Amino-2-phenethylamino-purin-9-yl)-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide 
• 124431-81-8 CGS 22902 
• 116856-32-7 (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide 
• 78795-27-4 (+/-)-1-<2'α,3'α-dihydroxy-4'β-hydroxymethylcyclopent-1'β-yl>-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 62138-01-6 (+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol 

Relevant academic research and scientific papers

A NOVEL AND EFFICIENT ROUTE TO CHIRAL 2-SUBSTITUTED CARBOCYCLIC 5'-N-ETHYL-CARBOXAMIDO-ADENOSINE (C-NECA)

A series of chiral 2-substituted-carbocyclic-NECA analogs was prepared in seven steps with an efficient resolution.The overall yield is good and can be applied to the other carbocyclic nucleosides.

A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines

The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.

Synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]hept-5-en-3-ones: Sodium borohydride-mediated carbon-nitrogen bond cleavage of five- and six-membered lactams

Various carbocyclic ribofuranosyl nucleosides were stereoselectively synthesized through a small number of steps from 2-azabicyclo[2.2.1]hept-5-en-3-ones by the use of sodium borohydride-mediated C-N bond cleavage as a key step. Ready availability of a no