130473-38-0

Basic information

• Product Name: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-
• Synonyms: 2,2-Dimethyl-6-(2-oxopropyl)-1,3-dioxin-4-one
• CAS NO: 130473-38-0
• Molecular Formula: C9H12O4
• Molecular Weight: 184.192
• Mol File: 130473-38-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 57-58 °C(Solv: hexane (110-54-3); toluene (108-88-3))
• Boiling Point: 303.5±42.0 °C(Predicted)
• Density: 1.109±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-(130473-38-0)
• EPA Substance Registry System: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-(130473-38-0)

Safety Data

• Hazardous Substances Data: 130473-38-0(Hazardous Substances Data)

Usage

Uses

2,2-Dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one, is a building block used in various chemical synthesis. It is used in the preparation of methylideneoxanone compounds and substituted derivatives as inhibitors of telomerase.

Upstream product

• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 75-36-5 acetyl chloride 
• 136801-79-1 6-(2-hydroxypropyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 2466-76-4 N-Acetylimidazole 

Downstream Products

• 1304104-48-0 4-[(4-methoxyphenyl)amino]-6-methyl-2H-pyran-2-one 
• 18735-96-1 2,3-Dihydro-2,7-dimethyl-4H,5H-pyrano-<4,3-b>-pyran-4,5-dion 
• 3749-51-7 4-hydroxy-6-methyl-2-pyridone 

Relevant articles and documents

Small molecule inhibitors of anthrax edema factor

Anthrax is a highly lethal disease caused by the Gram-(+) bacteria Bacillus anthracis. Edema toxin (ET) is a major contributor to the pathogenesis of disease in humans exposed to B. anthracis. ET is a bipartite toxin composed of two proteins secreted by the vegetative bacteria, edema factor (EF) and protective antigen (PA). Our work towards identifying a small molecule inhibitor of anthrax edema factor is the subject of this letter. First we demonstrate that the small molecule probe 5′-Fluorosulfonylbenzoyl 5′-adenosine (FSBA) reacts irreversibly with EF and blocks enzymatic activity. We then show that the adenosine portion of FSBA can be replaced to provide more drug-like molecules which are up to 1000-fold more potent against EF relative to FSBA, display low cross reactivity when tested against a panel of kinases, and are nanomolar inhibitors of EF in a cell-based assay of cAMP production.

Synthesis and Herbicidal Activity against Buffelgrass (Cenchrus ciliaris) of (±)-3-deoxyradicinin

A novel synthetic strategy for obtainment of (±)-3-deoxyradicinin (2) is reported. This synthetic methodology is more efficient than those previously reported in the literature and also shows higher versatility towards the introduction of different side-chains at both C-7 and C-2. The obtained compound (±)-2 shows phytotoxicity against the grass-weed buffelgrass comparable to that of the natural phytotoxin radicinin (1). Therefore, (±)-2 can constitute a more practical synthetic alternative to 1 as bioherbicide for buffelgrass control.

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H- benzo[h]chromen-2-one (ATBO) analogs were found to be significant in vitro anticancer agents in our previous research. Our continuing study has now discovered a new simplified (monocyclic rather than tricyclic) class of cytotoxic agents, 4-amino-2H-pyran-2-one (APO) analogs. By incorporating various substituents on the pyranone ring, we have established preliminary structure-activity relationships (SAR). Analogs 19, 20, 23, and 26-30 displayed significant tumor cell growth inhibitory activity in vitro. The most active compound 27 exhibited ED50 values of 0.059-0.090 μM.