130481-71-9Relevant academic research and scientific papers
Design and Synthesis of Orthogonally Protected D- and L-β-Hydroxyenduracididines from D-lyxono-1,4-Lactone
Lin, Cheng-Kun,Hou, Chung-Chien,Guo, Yi-Yong,Cheng, Wei-Chieh
, p. 5216 - 5219 (2016)
A practical synthesis of the orthogonally protected d- and l-β-hydroxyenduracididines (d- and l-βhEnds), the unique, nonproteinogenic α-amino acids found in mannopeptimycin antibiotics, is described. We appropriately applied d-lyxono-1,4-lactone derivativ
Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors
Rountree, J.S. Shane,Butters, Terry D.,Dwek, Raymond A.,Fleet, George W.J.
, p. 126 - 133 (2012/02/02)
2-Acetamido-1,4-imino-1,2,4-trideoxy-D-ribitol (DRBNAc) and the enantiomeric LRBNAc were prepared as potential hexosaminidase inhibitors from L- and D-lyxonolactone, respectively. Neither N-benzyl-DRBNAc nor N-benzyl-LRBNAc showed any inhibition of α- or
Efficient synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases
Rountree, J.S.Shane,Butters, Terry D.,Wormald, Mark R.,Dwek, Raymond A.,Asano, Naoki,Ikeda, Kyoko,Evinson, Emma L.,Nash, Robert J.,Fleet, George W.J.
, p. 4287 - 4291 (2008/02/12)
The synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc proceeded in an overall yield of 25%; the enantiomer, 2-acetamido-1,4-imino-1,2,4-trideoxy-d-arabinitol DABNAc, was prepared from l-lyxonolactone. LABNAc and N-
