130483-52-2

Upstream product

• 15754-20-8 (E)-acetophenone O-methyloxime 
• 630-19-3 pivalaldehyde 

Downstream Products

• 130483-75-9 2-Allyl-4,4-dimethyl-1-phenyl-pentane-1,3-dione 1-(O-methyl-oxime) 
• 1361388-12-6 1-(2-methoxy-3-phenyl-2H-azirin-2-yl)-2,2-dimethylpropan-1-one 
• 1361387-86-1 (Z)-2-diazo-1-(methoxyimino)-4,4-dimethyl-1-phenylpentan-3-one 
• 130483-66-8 (E)-1-(methoxyimino)-4,4-dimethyl-1-phenylpentan-3-one 

Relevant academic research and scientific papers

Expedient synthesis of highly substituted pyrroles via tandem rearrangement of α-diazo oxime ethers

An efficient rhodium-catalyzed synthesis of 2H-azirines and pyrroles has been developed. Novel rearrangement of α-oximino ketenes derived from α-diazo oxime ethers provides 2H-azirines bearing quaternary centers and allows for subsequent rearrangement to highly substituted pyrroles in excellent yields.

The Addition of Lithium Salts of O-Alkyloximes to Aldehydes: Synthesis of β-Keto O-Alkyloximes

Addition of lithium salts of oxime O-ethers to aldehydes affords the thermodynamically unfavored β-hydroxy (Z)-O-alkyloximes.Oxidation of the hydroxy function with chromium trioxide/pyridine complex gives the β-keto O-alkyloximes.Facile alkylation of the 1,3-dicarbonyl analogs is possible via their sodium or lithium salts.