130535-10-3Relevant academic research and scientific papers
RADIOLABELING AGENTS, METHODS OF MAKING, AND METHODS OF USE THEREOF
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Paragraph 0167; 0181, (2018/08/26)
Described herein are labeling agents, specifically [11C]fluoroform, [11C]difluoromethane, [11C]fluoromethyl iodide, [11C]fluoromethyl bromide, [11C]fluoromethyl chloride, [11C]fluoromethyl trifluoromethansulfonate, [11C]difluoromethyl iodide, [11C]difluoromethyl bromide, [11C]difluoromethyl chloride, [11C]difluoromethyl trifluoromethansulfonate, [11C]trifluoromethyl iodide, [11C]trifluoromethyl bromide, [11C]trifluoromethyl chloride, [11C]trifluoromethyl trifluoromethansulfonate, [18F]fluoroform, [18F]difluoromethane, [18F]difluoromethyl bromide or [18F]trifluoromethyl bromide. Also included are methods of labeling precursors to provide labeled fluoroalkanes and imaging methods.
A universal procedure for the [18F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity
Vanderborn, Dion,Sewing, Claudia,Herscheid,Windhorst, Albert D.,Orru, Romano V. A.,Vugts, Danielle J.
supporting information, p. 11046 - 11050 (2015/03/30)
Herein we describe a valuable method for the introduction of the [18F]CF3 group into arenes with highly improved specific activity by the reaction of [18F]trifluoromethane with aryl iodides or aryl boronic acids. This [su
Cu(i)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes
Rühl,Rafique,Lien,Riss
supporting information, p. 6056 - 6059 (2014/05/20)
This report is concerned with an efficient, CuI-mediated method for the radiosynthesis of [18F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Thr
A broadly applicable [ 18 F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging
Huiban, Mickael,Tredwell, Matthew,Mizuta, Satoshi,Wan, Zehong,Zhang, Xiaomin,Collier, Thomas Lee,Gouverneur, Veronique,Passchier, Jan
, p. 941 - 944 (2013/12/04)
Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission tomography. Currently, this molecular imaging technology is not exploited at its full potential because many 18 F-labelled probes are inaccessible or notoriously difficult to produce. Typical challenges associated with 18 F radiochemistry are the short half-life of 18 F (a high-priority demand for general methods allowing access to [ 18 F]CF 3 -substituted molecules for application in pharmaceutical discovery programmes. We report the development of a process for the late-stage [ 18 F]trifluoromethylation of (hetero)arenes from [ 18 F]fluoride using commercially available reagents and (hetero)aryl iodides. This [ 18 F]CuCF 3 -based protocol benefits from a large substrate scope and is characterized by its operational simplicity.
