130609-07-3

Upstream product

• 63-84-3 dopa 
• 56-40-6 glycine 
• 169267-05-4 C₂₀H₂₀⁽¹⁸⁾FNO₄ 
• 129841-03-8 3,4-methylenedioxy-6-[18F]flourobenzyl bromide 
• 90473-00-0 <(+)-2-hydroxypipanyl-3-idene>glycine ethyl ester 

Downstream Products

• 92812-82-3 [18F]-L-3,4-dihydroxy-6-fluorophenylalanine 

Relevant academic research and scientific papers

Direct arene C–H fluorination with 18F? via organic photoredox catalysis

Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C–H bonds, which limits advancements in PET radiotracer

No-carrier-added (NCA) synthesis of 6-[18F]fluoro-L-DOPA using 3,5,6,7,8,8a-hexahydro-7,7,8a-trimethyl-[6S-(6α, 8α, 8αβ)]-6,8-methano-2H-1,4-benzoxazin-2-one

3,5,6,7,8,8a-Hexahydro-7,7,8a-trimethyl-[6S-(6α.8α.8αβ)]6,8-methano-2H-1,4 -benzoxazino-2-one (2) was investigated as chiral auxiliary for asymmetric NCA nucleophilic synthesis of 6-[18]Fluoro-L-DOPA. Direct condensation of 3,4-dimethoxy-2-[su

Stabilization of radiosynthetic intermediates

The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabelled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scaveng

METHOD FOR THE PRODUCTION OF 18F-FLUORINATED ALPHA ACIDS

The invention relates to a method for the production of 18F-fluorinated ?-amino acids and 18F-fluorinated α-amino acid derivatives, comprising the following steps: (a) reaction of a 18F-fluorinated compound of formula I, w

NO-CARRIER ADDED (NCA) ARYL FLUORIDES VIA THE NUCLEOPHILIC AROMATIC SUBSTITUTION OF ELECTRON-RICH AROMATIC RINGS

Nucleophilic aromatic substitution by fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups.The reaction of (18)F- with a series of aromatic nitro aldehydes having protected hydroxyl substituents on the ring was studied.The reactivity of the aromatic ring towards nucleophilic substitution to give (18)F-labeled aromatic fluoroaldehyde derivatives is correlated with electron density at the reaction center.The effect of a number of protected hydroxyl substituents is reported. 13C-NMR was used as a sensitive probe for the changes in electron distribution at the ring carbon atoms.Radiochemical yield correlated with ppm values at the reaction center.This methodology has been applied to the synthesis of no-carrier-added(NCA) 6-fluoro-L-DOPA.The extension of this strategy to the syntheses of other labeled pharmaceuticals appears promising.