130640-32-3Relevant academic research and scientific papers
Total synthesis of (±)-, (-)-, and (+)-oudemansin X
Umezawa,Nozawa,Nagumo,Akita
, p. 1111 - 1118 (2007/10/02)
Three kinds of oudemansin X, (-)-1, (+)-1 and (±)-1, were totally synthesized. The key point in the present chiral synthesis was the enantioselective acetylation of the racemic alcohols, (±)-5 and (±)-8, using lipase in an organic solvent. The synthetic (-)-1 was found to exhibit strong antifungal activity against several molds and yeasts.
Utilisation of L-Quebrachitol in Natural Product Synthesis. Total Synthesis and Absolute Configuration of (-)-Oudemansin X
Chida, Noritaka,Yamada, Ken,Ogawa, Seiichiro
, p. 1957 - 1962 (2007/10/02)
The stereoselective conversion of the naturally occurring optically active cyclitol, L-quebrachitol 2, into antifungal β-methoxyacrylate, oudemansin X 1 is described.The first total synthesis of 1 fully confirmed the proposed absolute configuration of the
Total Synthesis of Antibiotic (-)-Oudemansin X Utilizing L-Quebrachitol as a Chiral Pool
Chida, Noritaka,Yamada, Ken,Ogawa, Seiichiro
, p. 687 - 690 (2007/10/02)
The stereoselective conversion of naturally occurring optically active cyclitol, L-quebrachitol (2), into antifungal (E)-β-methoxyacrylate, oudemansin X is described.This synthesis fully confirmed the proposed absolute configuration of the antibiotic and
