130660-15-0Relevant academic research and scientific papers
The superiority of properly prepared lithium 1-N,N-dimethylaminonaphthalenide (LDMAN) over other aromatic radical-anions for the generation of organolithiums by reductive lithiation
Ivanov, Roman,Marek, Ilan,Cohen, Theodore
, p. 174 - 176 (2010)
The use of lithium 1-N,N-dimethylaminonaphthalenide (LDMAN) is found to be considerably superior in yield, ease of operation, and cost to the far more widely used lithium p,p′-di-tert-butylbiphenylide (LDBB) in reductive lithiations by aromatic radical-an
A General Preparative Method for Carbonyl-Protected γ-Lithioketones via Reductive Lithiation. Synthetic Uses of the Bishomoenolate Equivalents
Cohen, Theodore,Zhang, Birong,Cherkauskas, John P.
, p. 11569 - 11584 (2007/10/02)
The mixed cuprates, generated by reductive lithiation of bis(phenylthio)acetals using lithium 4,4'-di-tert-butylbiphenylide (LDBB), followed by addition of cuprous bromide-dimethyl sulfide complex, undergo conjugate addition to enones in the presence of t
Generation, rearrangements and some synthetic uses of bishomoallyllithiums
Chen, Fangping,Mudryk, Boguslaw,Cohen, Theodore
, p. 12793 - 12810 (2007/10/02)
A general preparative method for bishomoallyllithiums consists of reductive lithiation by 4,4'-di-tert-butylbiphenylide (LDBB) of bishomoallyl phenyl sulfides, which can be prepared by (1) thioacetalization of γ, δ-unsaturated ketones followed by replacin
CONJUGATE REDUCTION OF POLYFUNCTIONAL α,β-UNSATURATED CARBONYL COMPOUNDS USING 6. COMPATIBILITY WITH HALOGEN, SULFONATE, AND SULFUR SUBSTITUENTS
Koenig, Thomas M.,Daeuble, John F.,Brestensky, Donna M.,Stryker, Jeffrey M.
, p. 3237 - 3240 (2007/10/02)
In contrast to organocuprate conjugate addition and standard methods for conjugate reduction, use of the stable copper(I) hydride cluster, 6, allows chemoselective conjugate reduction of α,β-unsaturated carbonyl compounds substituted at the γ-position with leaving groups.In addition, the compatibility of the conjugate reduction with organic halides and sulfonate groups is demonstrated.
