130755-47-4

Upstream product

• 75-69-4 trichlorofluoromethane 
• 882-33-7 diphenyldisulfane 
• 701-65-5 (trichloromethylthio)benzene 

Downstream Products

• 1334160-30-3 (dichlorofluoromethyl)(imino)(phenyl)-λ⁶-sulfanone 
• 1334160-28-9 N-(acetyl) dichlorofluoromethyl phenyl sulfoximine 
• 331463-24-2 1-chloro-1-fluoro-1-phenylsulfonyl-2-heptanol 
• 331463-26-4 1-chloro-1-fluoro-1-phenylsulfonyl-4-methyl-2-pentanol 
• 140243-94-3 1-chloro-1-fluoromethyl phenyl sulfone 
• 140137-89-9 chlorofluoromethyl phenyl sulfoxide 
• 5433-76-1 diphenylmethyl phenyl sulfone 
• 19523-24-1 1-methyl-4-((phenylsulfonyl)methyl)benzene 
• 3112-88-7 Benzyl phenyl sulfone 
• 331463-16-2 (dichloro-fluoro-methanesulfonyl)-benzene 
• 882-33-7 diphenyldisulfane 
• 116109-54-7 chlorofluoromethyl phenyl sulfide 
• 100-68-5 methyl-phenyl-thioether 
• 78725-90-3 S-phenyl-O-ethyl thiolcarbonate 

Relevant academic research and scientific papers

Microwave-assisted aliphatic fluorine-chlorine exchange using triethylamine trihydrofluoride (TREAT-HF)

Aliphatic fluorine-chlorine exchange reactions can be performed under microwave conditions using TREAT-HF as a mild and selective fluorination reagent. The highly polar TREAT-HF couples efficiently with microwave irradiation and reaction temperatures of 250 °C can be reached within 30 s. Under these conditions dichloromethyl- and trichloromethyl substrates can be converted into the corresponding fluoro analogs within 5 min. In order to prevent corrosion of borosilicate reaction vessel at high temperatures the use of sintered silicon carbide microwave vials is introduced.

Chemistry of trichlorofluromethane: Synthesis of chlorofluromethyl phenyl sulfone and fluoromethyl phenyl sulfone and some of their reactions

It was observed that the reaction of CFCl3 with thiophenoxide gave only 10% of the corresponding thioether. On the other hand, these thioethers could be prepared in excellent yield from diaryl disulfides and CFCl3 in the presence of sodium hydroxymethanesulfinate in aqueous DMF at 4 atm pressure of nitrogen. Dechlorination of the thioether (PhSCFCl2) with different reducing agents were studied. Most of the reducing agents eliminated both fluorine and chlorine functionalities or gave the hydrolyzed products. But its sulfone on treatment with Zinc in methanol gave monochlorofluoromethyl and fluoromethyl phenyl sulfone in good yields. Darzens reaction of these compounds was also studied.

Process for the preparation of perhaloalkylthioethers

The present invention relates to a process for the preparation of perhaloalkylthioethers by bringing a perhaloalkyl halide, preferably a bromide or an iodide, into contact with a disulphide in the presence of zinc and of sulphur dioxide or of a dithionite or of a hydroxymethanesulphinate or of a formate anion and sulphur dioxide.