1307853-43-5

Basic information

• Product Name: (2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl acetate
• Synonyms: (2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl acetate
• CAS NO: 1307853-43-5
• Molecular Weight: 384.437
• Mol File: 1307853-43-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl acetate(1307853-43-5)
• EPA Substance Registry System: (2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl acetate(1307853-43-5)

Safety Data

• Hazardous Substances Data: 1307853-43-5(Hazardous Substances Data)

Upstream product

• 1485-70-7 N-benzylbenzamide 
• 98-88-4 benzoyl chloride 
• 100-46-9 benzylamine 
• 873-75-6 4-bromobenzenemethanol 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 21388-92-1 4-bromobenzyl acetate 

Relevant articles and documents

Single-Component Phosphinous Acid Ruthenium(II) Catalysts for Versatile C-H Activation by Metal-Ligand Cooperation

Well-defined ruthenium(II) phosphinous acid (PA) complexes enabled chemo-, site-, and diastereoselective C-H functionalization of arenes and alkenes with ample scope. The outstanding catalytic activity was reflected by catalyst loadings as low as 0.75 mol %, and the most step-economical access reported to date to angiotensin II receptor antagonist blockbuster drugs. Mechanistic studies indicated a kinetically relevant C-X cleavage by a single-electron transfer (SET)-type elementary process, and provided evidence for a PA-assisted C-H ruthenation step. A blockbuster catalyst: Well-defined ruthenium(II) phosphinous acid (PA) complexes were identified as powerful catalysts for highly selective C-H arylations with ample scope, which enabled low catalyst loadings and gave step-economical access to blockbuster drugs. Mechanistic studies were supportive of a PA-assisted C-H activation.

Efficient catalytic system for Ru-catalyzed C-H arylation and application to a practical synthesis of a pharmaceutical

A series of K salts of sulfonic acids have been tested as a cocatalyst for Ru-catalyzed C-H arylation. Among them, K 2, 4, 6-trimethylbenzenesulfonate (TMBSK) was found to be most active, and generality of the reaction was confirmed for a variety of nitrogen-containing heterocycles to give corresponding functionalized biaryls in high yields. The present methodology was applied to a practical synthesis of Candesartan Cilexetil.