21388-92-1

Basic information

• Product Name: Benzenemethanol, 4-bromo-, acetate
• Synonyms: Benzenemethanol, 4-bromo-, acetate (9CI);Benzyl alcohol, p-bromo-, acetate (6CI,8CI);4-(Acetoxymethyl)bromobenzene
• CAS NO: 21388-92-1
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.073
• Mol File: 21388-92-1.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 265.397 °C at 760 mmHg
• Flash Point: 114.309 °C
• Density: 1.446 g/cm³
• CAS DataBase Reference: Benzenemethanol, 4-bromo-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-bromo-, acetate(21388-92-1)
• EPA Substance Registry System: Benzenemethanol, 4-bromo-, acetate(21388-92-1)

Safety Data

• Hazardous Substances Data: 21388-92-1(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 4-bromo-, acetate is a chemical compound with the molecular formula C9H9BrO2. It is commonly used in organic synthesis and pharmaceutical research as a reagent for the preparation of various organic compounds. Benzenemethanol, 4-bromo-, acetate is often used as a precursor in the production of pharmaceuticals and agrochemicals. It is a colorless liquid with a molecular weight of 227.07 g/mol. Benzenemethanol, 4-bromo-, acetate is also known by its CAS number 5026-62-0 and is classified as a hazardous substance, requiring proper handling and storage.

Upstream product

• 106-38-7 para-bromotoluene 
• 64-19-7 acetic acid 
• 873-75-6 4-bromobenzenemethanol 
• 108-24-7 acetic anhydride 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 
• 108-05-4 vinyl acetate 
• 130534-91-7 1-bromo-4-[(methoxymethyloxy)methyl]benzene 
• 216443-67-3 4-bromo-1-[(ethoxymethoxy)methyl]benzene 
• 75-36-5 acetyl chloride 
• 141-78-6 ethyl acetate 
• 86605-93-8 (4-bromobenzyloxy)trimethylsilane 
• 127-09-3 sodium acetate 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 873-75-6 4-bromobenzenemethanol 
• 145040-37-5 candesartan cilexetil 
• 114798-36-6 2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde 
• 676129-93-4 (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid benzyl ester 
• 1215298-35-3 methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate 
• 1307853-85-5 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 1-({4-[2-(1-benzyl-1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate 
• 114798-26-4 lorsartan 
• 1301606-95-0 {2'-[1-(o-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}-methanol 
• 1307853-55-9 benzyl N-({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-L-valinate 
• 1307853-40-2 5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole 
• 1307853-69-5 methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate 
• 1307853-71-9 methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate 
• 1307853-72-0 methyl 2-[({2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate 
• 1307853-80-0 methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate 

Relevant articles and documents

Fe3O4@PEG core/shell nanoparticles as magnetic nanocatalyst for acetylation of amines and alcohols using ultrasound irradiations under solvent-free conditions

Abstract: Ultrasound irradiation was used to prepare one-pot Fe3O4@PEG core/shell nanostructure for the first time. The morphology, structure, and physicochemical properties were specified by different analytical techniques including field emission scanning electron microscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, X-ray powder diffraction, and vibrating sample magnetometer. For acetylation of phenols, alcohols, and amines, the synthesized Fe3O4@PEG core/shell nanoparticles were used as an efficient heterogeneous and green catalyst with acetic anhydride under sonication applying mild reaction conditions. Different electron-withdrawing and electron-donating substrates indicate a prominent yield of desired products with the merit of reusability of Fe3O4@PEG nanocatalyst and magnetic separation. Graphical Abstract: [Figure not available: see fulltext.].

Enantioselective Synthesis of cis- A nd trans-Borocyclopropylmethanol: Simple Building Blocks to Access Heterocycle-Substituted Cyclopropylmethanols

An enantioselective and non-oxidative methodology was developed to obtain enantioenriched cyclopropyl boronates using a diethanolamine-promoted selective decomplexation of dioxaborolane. The non-oxidative decomplexation of the dioxaborolane ligand from the cyclopropylmethoxide species formed in the dioxaborolane-mediated Simmons-Smith cyclopropanation reaction provided the enantio?-enriched CIDA-based (CIDA = N-cyclohexyliminodiacetic acid) boro?-cyclopropane in 92% yield and 95.6:4.4 er. A robustness screen has shown diethanolamine to be compatible with esters, carbamates and N-heterocycles, providing a tool to access enantioenriched cyclopropanes carrying not only base-sensitive but oxidizable functional groups as well. Diethanolamine was found to be compatible with the modified zinco-cyclopropanation reaction of allyl alcohol to remove residual dioxaborolane from the corresponding cis-N-heterocycle cyclopropylmethanol, thereby leading to improved yields.

Preparation of Polydopamine Sulfamic Acid-Functionalized Silica Gel as Heterogeneous and Recyclable Nanocatalyst for Acetylation of Alcohols and Amines Under Solvent-Free Conditions

To fabricate SiO2/PDA–SO3H nanocatalyst, a suitable method is designed for the loading of sulfonic acid groups on the surface of polydopamine (PDA)-encapsulated SiO2 nanoparticles. To bridge the gap between heterogeneous and homogeneous catalysis, surface functionalization of silica gel is an elegant procedure. The morphology, structure, and physicochemical features were specified using different analytical techniques including field emission scanning electron microscopy (FESEM), Fourier transformed infrared spectroscopy (FT-IR), high resolution-transmission electron microscopy (HR-TEM), energy dispersive X-ray spectroscopy (EDS), wavelength-dispersive X-ray spectroscopy (WDX), X-ray photoelectron spectroscopy (XPS), and back titration. The SiO2/PDA–SO3H nanoparticles are efficient nanocatalysts for the acetylation of many alcohols, phenols, and amines with acetic anhydride under solvent-free conditions in good to excellent yields. Moreover, the reuse and recovery of the catalyst was shown seven times without detectible loss in activity. Graphical Abstract: [Figure not available: see fulltext.]