13079-20-4

Basic information

• Product Name: ()-2-amino-4-methylvaleramide
• Synonyms: Pentanamide, 2-amino-4-methyl-; (1)-2-Amino-4-methylvaleramide; leucinamide
• CAS NO: 13079-20-4
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.1882
• EINECS: 235-983-7
• Mol File: 13079-20-4.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 250.9°C at 760 mmHg
• Flash Point: 105.6°C
• Density: 0.98g/cm³
• Vapor Pressure: 0.0211mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: ()-2-amino-4-methylvaleramide(CAS DataBase Reference)
• NIST Chemistry Reference: ()-2-amino-4-methylvaleramide(13079-20-4)
• EPA Substance Registry System: ()-2-amino-4-methylvaleramide(13079-20-4)

Safety Data

• Hazardous Substances Data: 13079-20-4(Hazardous Substances Data)

Usage

General Description

()-2-amino-4-methylvaleramide is a chemical compound with the molecular formula C6H14N2O. It is an amide derivative of 4-methylvaleric acid and contains an amino group, making it an important building block in organic synthesis. ()-2-amino-4-methylvaleramide is used in pharmaceutical research and drug development, particularly in the synthesis of potential antimicrobial and antifungal agents. Additionally, it has been studied for its potential role in the treatment of neurological disorders and as an intermediate in the production of various organic compounds. The exact properties and uses of ()-2-amino-4-methylvaleramide are still being explored, and its potential applications in various fields make it an important compound for further research and development.

Upstream product

• 2899-43-6 DL-leucine ethyl ester 
• 65451-12-9 (RS)-leucinonitrile 
• 61-90-5 L-leucine 
• 869-19-2 Glycyl-L-leucine 
• 7664-41-7 ammonia 
• 3350-19-4 (tert-butoxycarbonyl)-L-leucine p-nitrobenzylester 
• 2666-93-5 (S)-Leu-OMe 
• 35661-60-0 Fmoc-Leu-OH 
• 139551-97-6 (S)-(9H-fluoren-9-yl)methyl (1-Amino-4-methyl-1-oxo-pentan-2-yl)carbamate 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 60117-24-0 H-Tyr-Gly-Gly-Phe-Leu-NH₂ 
• 106827-71-8 Trt-L-Hse(Trt)-L-Leu-NH₂ 
• 65356-77-6 N-acetyl-L-triptophanyl-L-leucine amide 

Downstream Products

• 15893-47-7 (R)-2-amino-4-methylpentanamide 
• 61-90-5 L-leucine 
• 70497-43-7 Carbobenzoxy-S-benzyl-cysteinyl-leucinamid-(L,L) 
• 17193-48-5 Z-(β-O-Bz-Asp)-Leu-NH2 
• 65732-64-1 4-Methyl-2-(2-nitro-phenylsulfanylamino)-pentanoic acid amide 
• 59937-71-2 (S)-4-Methyl-2-(2-nitro-phenylsulfanylamino)-pentanoic acid amide 
• 13162-85-1 3-(2-methylpropyl)-6-phenyl-2(1H)-pyrazinone 
• 128972-00-9 3-(2-methylpropyl)-5-phenyl-2(1H)-pyrazinone 
• 159141-35-2 [(1S,2R)-1-Benzyl-2-((S)-1-carbamoyl-3-methyl-butylamino)-2-cyano-ethyl]-carbamic acid tert-butyl ester 
• 159247-02-6 [(1S,2S)-1-Benzyl-2-((S)-1-carbamoyl-3-methyl-butylamino)-2-cyano-ethyl]-carbamic acid tert-butyl ester 
• 95303-78-9 Z-L-Val-L-Leu-NH₂ 
• 17331-91-8 N-CBZ-L-Tyr-L-LeuNH₂ 
• 65118-58-3 N-Ac-L-Phe-L-Leu-NH₂ 
• 74257-73-1 tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 

Relevant articles and documents

SELECTIVE RACEMIZATION OF AMINO ACID AMIDES IN THE PRESENCE OF AMINO ACIDS

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DESIGN AND SYNTHESIS OF A MULTI-DETACHABLE BENZHYDRYLAMINE-RESIN FOR SOLID PHASE PEPTIDE SYNTHESIS

Peptides with C-terminal α-carboxamides were synthesized from a multi-detachable benzhydrylamine-resin containing a Boc-(4-acetoxy)benzhydrylamine handle of unambiguous origin.The peptides bound to the new resin are stable to trifluoroacetic acid, but are cleavable by hydrogen fluoride, base and nucleophiles to give unprotected or protected peptide fragments.

Enzymatic stability of myostatin inhibitory 16-mer peptides

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HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.