130794-93-3

Upstream product

• 114863-45-5 3,4-Dibenzoyl-2-desoxy-D-ribopyranose 
• 108-24-7 acetic anhydride 
• 452-51-7 D-2-deoxyribose 
• 98-88-4 benzoyl chloride 
• 25874-16-2 3,4-di-O-benzoyl-D-arabinal 
• 64-19-7 acetic acid 

Downstream Products

• 130703-15-0 C₂₃H₂₁N₃O₆ 
• 130703-09-2 C₂₄H₂₁N₅O₅ 
• 155976-46-8 C₂₄H₂₂N₂O₇ 
• 7697-49-6 9-(2-Deoxy-beta-D-erythro-pentopyranosyl)-adenine 
• 17434-50-3 9-(2-Deoxy-alpha-D-erythro-pentopyranosyl)-adenine 
• 13091-57-1 1-(2'-Desoxy-α-D-ribopyranosyl)-thymin 
• 163110-84-7 3,4-di-O-benzoyl-2-deoxy-β-D-ribopyranosyl cyanide 
• 163110-83-6 3,4-di-O-benzoyl-2-deoxy-α-D-ribopyranosyl cyanide 

Relevant academic research and scientific papers

Thio-click reaction of 2-deoxy-exo-glycals towards new glycomimetics: stereoselective synthesis of C-2-deoxy-d-glycopyranosyl compounds

A series of 2-deoxy-glycopyranosyl cyanides with d-arabino, d-lyxo, d-erythro, and d-threo configurations was synthesized from the corresponding glycals via 2-deoxy-glycopyranosyl acetates. The cyanides were transformed to anhydro-aldose tosylhydrazones by reduction with NaH2PO2/Ra-Ni in the presence of tosylhydrazine. The tosylhydrazones furnished 2-deoxy-exo-glycals under modified Bamford-Stevens conditions. Photoinitiated thiol-ene additions of these exo-glycals resulted in the corresponding C-(2-deoxy-d-glycopyranosyl)methyl sulfides in medium to good yields with exclusive regio- and stereoselectivities in most cases. Several disaccharide mimics with a C-S moiety in place of the glycosidic oxygen were also obtained.

Improved procedure for the regiospecific synthesis of 2'-deoxyribonucleosides

2'-Deoxyribonucleosides are regiospecifically synthesized in high yields by catalyzing with KI-dibenzo-18-crown-6 PTC the condensation between unprotected silylated purines and pyrimidines and the appropriate easily available 2-deoxy-ribofuranosyl or pyranosyl sugar derivatives.