13080-10-9

Usage

Uses

Used in Pharmaceutical Applications:
4-Amino-2-phenylbutanoic acid is used as a therapeutic agent for treating anxiety and insomnia. It functions by binding to GABA receptors in the brain, which leads to a calming and relaxing effect, making it beneficial for individuals suffering from these conditions.
Used in Neurological Disorders Treatment:
In the field of neurology, 4-Amino-2-phenylbutanoic acid is used as a treatment for various neurological disorders. Its anxiolytic and sedative effects contribute to the management of symptoms associated with these disorders, providing relief and improving the quality of life for patients.
However, it is important to note that 4-Amino-2-phenylbutanoic acid, or phenibut, can be addictive and is associated with withdrawal and tolerance. Therefore, its use should be carefully monitored and conducted under medical supervision to ensure safety and effectiveness.

InChI:InChI=1/C10H13NO2.ClH/c11-7-6-9(10(12)13)8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H,12,13);1H

Upstream product

• 6837-08-7 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 88970-65-4 β-(carbomethoxy)-β-phenylpropionitrile 
• 103-82-2 phenylacetic acid 
• 442542-97-4 (+/-)-3-cyano-2-phenylpropionic acid 
• 64-18-6 formic acid 
• 4360-51-4 cinnamylamine 
• 22049-96-3 2-oxo-3-phenyl-pyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 6837-08-7 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid 
• 442542-99-6 N-phthalyl-3-amino-2-phenylbutyric acid pantolactonyl ester 
• 442542-98-5 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid chloride 

Relevant academic research and scientific papers

A simple synthesis of γ-aminoacids

The addition of dianions of carboxylic acids to bromoacetonitrile, leads, in good yields, to the corresponding γ-cyanoacids that give γ-aminoacids on hydrogenation. This two-step methodology improves the results previously described.

An efficient synthesis of γ-aminoacids and attempts to drive its enantioselectivity

Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields, to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. This two step methodology improves upon previously described results. Poor e.e's resulted from

Stereoselective synthesis of both enantiomers of N-Boc-α-aryl- γ-aminobutyric acids

Esterification of racemic α-aryl-β-cyanopropionic acid chlorides with either (R)- or (S)-N-phenylpantolactam as the chiral auxiliary in the presence of Et3N resulted in the predominant formation of (αR,3′R)- or (αS,3′S)-configured pantolactam c

Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

The synthesis of (±)-N-phthalyl α-phenyl-γ-aminobutyric acid and its asymmetric transformation via ketene formation have been investigated, allowing, after hydrolysis and amine protection, the preparation of the enantiomerically pure N-Boc-(R)-α-phenyl-γ-

FLAME-INDUCED CARBOXYLATION OF UNSATURATED AMINES IN AN AQUEOUS FORMIC ACID SOLUTION

When a hydrogen-oxygen flame was kept in contact with an aqueous formic acid solution of unsaturated amines, carboxylation onto a double bond took place.This reaction revealed to be initiated by addition of a hydrogen atom to the double bond followed by coupling of the resulted substrate radical with a carboxyl radical.