13080-10-9

Basic information

• Product Name: 4-Amino-2-phenylbutanoic acid
• Synonyms: 4-amino-2-phenylbutanoic acid;2-Phenyl-4-aminobutanoic acid;α-Phenyl GABA
• CAS NO: 13080-10-9
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 13080-10-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 200-202 °C
• Boiling Point: 328.9°Cat760mmHg
• Flash Point: 152.7°C
• Appearance: /
• Density: 1.161
• Vapor Pressure: 7.39E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-2-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-phenylbutanoic acid(13080-10-9)
• EPA Substance Registry System: 4-Amino-2-phenylbutanoic acid(13080-10-9)

Safety Data

• Hazardous Substances Data: 13080-10-9(Hazardous Substances Data)

Usage

General Description

4-Amino-2-phenylbutanoic acid is a chemical compound that is also known as phenibut. It is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is commonly used as a nootropic and anxiolytic agent. Phenibut has been shown to have sedative and anxiety-reducing effects, and is used to treat anxiety, insomnia, and other neurological disorders. It acts by binding to GABA receptors in the brain, resulting in a calming and relaxing effect. However, phenibut can be addictive and is associated with withdrawal and tolerance, so it should be used carefully and under medical supervision.

InChI:InChI=1/C10H13NO2.ClH/c11-7-6-9(10(12)13)8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H,12,13);1H

Upstream product

• 442542-97-4 (+/-)-3-cyano-2-phenylpropionic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 88970-65-4 β-(carbomethoxy)-β-phenylpropionitrile 
• 103-82-2 phenylacetic acid 
• 64-18-6 formic acid 
• 4360-51-4 cinnamylamine 
• 22049-96-3 2-oxo-3-phenyl-pyrrolidine-3-carboxylic acid methyl ester 
• 6837-08-7 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid 

Downstream Products

• 442542-99-6 N-phthalyl-3-amino-2-phenylbutyric acid pantolactonyl ester 
• 442542-98-5 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid chloride 
• 6837-08-7 N-phthalyl-(+/-)-4-amino-2-phenylbutyric acid 

Relevant articles and documents

A simple synthesis of γ-aminoacids

The addition of dianions of carboxylic acids to bromoacetonitrile, leads, in good yields, to the corresponding γ-cyanoacids that give γ-aminoacids on hydrogenation. This two-step methodology improves the results previously described.

Stereoselective synthesis of both enantiomers of N-Boc-α-aryl- γ-aminobutyric acids

Esterification of racemic α-aryl-β-cyanopropionic acid chlorides with either (R)- or (S)-N-phenylpantolactam as the chiral auxiliary in the presence of Et3N resulted in the predominant formation of (αR,3′R)- or (αS,3′S)-configured pantolactam c

FLAME-INDUCED CARBOXYLATION OF UNSATURATED AMINES IN AN AQUEOUS FORMIC ACID SOLUTION

When a hydrogen-oxygen flame was kept in contact with an aqueous formic acid solution of unsaturated amines, carboxylation onto a double bond took place.This reaction revealed to be initiated by addition of a hydrogen atom to the double bond followed by coupling of the resulted substrate radical with a carboxyl radical.