130800-04-3

Basic information

• Product Name: 1,2-phenylenebis(ethane-2,1-diyl) diMethanesulfonate
• Synonyms: 1,2-phenylenebis(ethane-2,1-diyl) diMethanesulfonate;1,2-Bis(2-methylsulfonyloxyethyl)benzene
• CAS NO: 130800-04-3
• Molecular Formula: C₁₂H₁₈O₆S₂
• Molecular Weight: 322.39772
• Mol File: 130800-04-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-phenylenebis(ethane-2,1-diyl) diMethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-phenylenebis(ethane-2,1-diyl) diMethanesulfonate(130800-04-3)
• EPA Substance Registry System: 1,2-phenylenebis(ethane-2,1-diyl) diMethanesulfonate(130800-04-3)

Safety Data

• Hazardous Substances Data: 130800-04-3(Hazardous Substances Data)

Usage

Chemical structure

1,2-Phenylenebis(ethane-2,1-diyl) with two methanesulfonate groups attached

Common uses

Crosslinking agent in organic synthesis and polymer chemistry, production of resins and adhesives, manufacture of pharmaceuticals and agrochemicals

Properties

Forms strong covalent bonds with different molecules and polymers, provides high strength and durability

Importance

Wide range of applications in various industries

Upstream product

• 7500-53-0 1,2-Phenylenediacetic acid 
• 17378-99-3 2,2’-(1,2-phenylene)diethanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 34583-83-0 7-nitro-2,3,4,5-tetrahydro-1H-benzo[d]azepiney 
• 4424-20-8 2,3,4,5-tetrahydro-1H-3-benzazepine 
• 130800-05-4 1,2-Bis(2'-iodoethyl)benzene 

Relevant articles and documents

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

HETEROCYCLIC COMPOUNDS AS AXL INHIBITORS

Compounds of Formula I and their uses of effective AXL inhibitors and for the treatment of physical condition mediated by AXL.

FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Tetrahydrobenzazepines and their use

The invention relates to tetrahydrobenzazepines of the general formula I in which the variables Ar, A, B, Y, R1 and R2 have the meaninigs indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid addition salts of these compounds and the physiologically tolerated acid addition salts of the N-oxides. The invention also relates to a pharmaceutical compositon that comprises at least one tetrahydrobenzazepine compound of the formula I, the physically tolerated acid addition salt of I, the N-oxide of compound of the formula I and/or the physically tolerated acid addition salts of the N-oxides of I, and further to the use of a compound according to the present invention for treating disorders that respond benefically to dopamine D3 receptor antagonists or dopamine D3 agonists. The compounds according to the invention are preferably useful for the treatment of disorders of the central nervous system such as schizophrenia and depression and for the treatment of renal function disorders.

A New General Synthesis of Polycyclic Aromatic Compounds Based on Enamine Chemistry

Alkylation of enamines and enamine salts by benzylic and (β-haloethyl)aryl halides, respectively, followed by acidic cyclodehydration and dehydrogenation provides an efficient synthetic approach to a wide range of polycyclic aromatic compounds of diverse structural types.Specific polycyclic hydrocarbons synthesized by this route include benzo- and benzofluorene, 7H-dibenzo-, 13H-dibenzo-, and 13H-dibenzofluorene, 15H-tribenzofluorene, dibenzochrysene, benzopentaphene, indenofluorene, fluorenofluorene, octahydrodibenzanthracene, dibenzanthracene, octahydrodibenzanthracene, dibenzanthracene, picene, benzopicene, 1H-benzaceanthrylene, and 4H-cyclopentachrysene.This method with appropriate modifications appears to be potentially broader in scope than established traditional methods of polycyclic hydrocarbon synthesis.