130867-58-2

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 130867-57-1 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 133510-69-7 Methoxy-acetic acid (2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-((3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethoxymethyl)-tetrahydro-furan-3-yl ester 
• 133510-55-1 C₄₃H₄₆N₄O₁₆ 
• 133510-64-2 (S)-3-[(2R,3S,5R)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-methoxy-acetoxy)-tetrahydro-furan-2-ylmethoxymethoxy]-2-benzyloxycarbonylamino-propionic acid benzyl ester 
• 133510-66-4 Methoxy-acetic acid (2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(bis-benzyloxy-phosphoryloxymethoxymethyl)-tetrahydro-furan-3-yl ester 
• 133527-00-1 5'-O-levulinoyl-3'-O-(4-pentenyloxymethyl)-N³-benzoyl-thymidine 
• 133510-53-9 5'-O-levulinoyl-3'-O-methylthiomethyl-N³-benzoyl-thymidine 
• 133510-61-9 5'-O-methylthiomethyl-3'-O-methoxyacetyl-N³-benzoyl-thymidine 
• 133510-54-0 3-Benzoyl-1-((2R,4S,5R)-5-hydroxymethyl-4-pent-4-enyloxymethoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 133510-52-8 3-Benzoyl-1-((2R,4S,5R)-5-hydroxymethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 133510-59-5 C₆₁H₆₄N₆O₂₂ 
• 130887-31-9 C₆₅H₇₁N₆O₁₅P 
• 130867-64-0 C₅₉H₅₈N₄O₁₆ 
• 130867-68-4 C₅₆H₅₄N₄O₁₄ 
• 130867-65-1 C₃₈H₄₀N₄O₁₄ 

Relevant academic research and scientific papers

An efficient approach to the synthesis of thymidine derivatives containing phosphate-isosteric methylene acetal linkages

Iodonium ion promoted condensation of properly protected 3′-O-methylthiomethyl or 3′-O-(4-penten-1-oxymethyl)-thymidine with 3′-O-methoxyacetyl-thymidine, was explored. A judicious choice of the iodoinium source and protecting groups led to an efficient preparation of thymidine dimers having internucleosidic-3′5′)-methylene bonds. The latter procedure was utilized towards the synthesis, in solution and on a solid support, of DNA-fragments containing one or more T-CII2-T dimers. Further, 5′-O-methylthiomethyl-3′-O-methoxyacetyl-N 3-benzoyl-thymidine proved to be a suitable donor for the introduction of 5′-O-methylene acetal-linkage s between 2,3,4,6-tetra-Obenzyl-D-glucose, benzyl N-benzyloxycarbonyl-L-serine and dibenzyl phosphate.

SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING THYMIDINES LINKED VIA AN INTERNUCLEOSIDIC-(3'-5')-METHYLENE BOND

Condensation of N3-benzoyl-5'-O-dimethoxytrityl-3'-O-(4-penten-1-oxomethyl)-thymidine with N3-benzoyl-3'-O-methoxyacetyl-thymidine, in the presence of N-iodosuccinimide, afforded a fully-protected thymidine dimer having an internucle