130874-31-6

Basic information

• Product Name: 4-bromo-3-methyl-1-phenylsulphonylpyrazole
• Synonyms: 4-bromo-3-methyl-1-phenylsulphonylpyrazole
• CAS NO: 130874-31-6
• Molecular Weight: 301.164
• Mol File: 130874-31-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-3-methyl-1-phenylsulphonylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3-methyl-1-phenylsulphonylpyrazole(130874-31-6)
• EPA Substance Registry System: 4-bromo-3-methyl-1-phenylsulphonylpyrazole(130874-31-6)

Safety Data

• Hazardous Substances Data: 130874-31-6(Hazardous Substances Data)

Upstream product

• 121358-73-4 4-bromo-1-phenylsulphonylpyrazole 
• 74-88-4 methyl iodide 
• 98-09-9 benzenesulfonyl chloride 
• 13808-64-5 4-bromo-3-methyl-1H-pyrazole 

Downstream Products

• 13808-64-5 4-bromo-3-methyl-1H-pyrazole 

Relevant articles and documents

Pyrazole Chemistry. Part 4. Directed Lithiation of 4-Bromo-1-phenylsulphonylpyrazole: a Convenient Approach to Vicinally Disubstituted Pyrazoles

4-Bromo-1-phenylsulphonylpyrazole (10), obtained from 4-bromopyrazole (5) and benzenesulphonyl chloride, can be metallated regioselectively by phenyl-lithium to give the 5-lithio derivative (15) which upon quenching with appropriate electrophiles leads to the 4-bromo-1-phenylsulphonyl-5-substituted pyrazoles (16)-(23), (25), and (26).Compounds (22), (23), and (25) were found to undergo isomerisation to afford the thermodynamically more stable 4-bromo-1-phenylsulphonyl-3-substituted pyrazoles (11), (24), and (13) under the reaction conditions applied.The phenylsulphonyl protecting group then can be removed readily under alkaline conditions to yield the corresponding 4-bromo-3(5)-substituted 1H-pyrazoles (6), (9), (28), (29), and (30).