1309608-05-6Relevant articles and documents
Identification and initial SAR of silybin: An Hsp90 inhibitor
Zhao, Huiping,Brandt, Gary E.,Galam, Lakshmi,Matts, Robert L.,Blagg, Brian S.J.
, p. 2659 - 2664 (2011)
Through Hsp90-dependent firefly luciferase refolding and Hsp90-dependent heme-regulated eIF2α kinase (HRI) activation assays, silybin was identified as a novel Hsp90 inhibitor. Subsequently, a library of silybin analogues was designed, synthesized and evaluated. Initial SAR studies identified the essential, non-essential and detrimental functionalities on silybin that contribute to Hsp90 inhibition.