131-76-0 Usage
General Description
1-Benzofuran-2,3-dicarboxylic acid is a chemical compound with the molecular formula C10H6O5. It is a derivative of benzofuran and belongs to the class of dicarboxylic acids. 1-BENZOFURAN-2,3-DICARBOXYLIC ACID has potential applications in organic synthesis and pharmaceutical research due to its unique structure and reactivity. It can be used as a building block for the synthesis of various heterocyclic compounds and can also act as a ligand for coordination chemistry. Additionally, 1-benzofuran-2,3-dicarboxylic acid has demonstrated potential biological activities, making it an interesting target for further study in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 131-76-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 131-76:
(5*1)+(4*3)+(3*1)+(2*7)+(1*6)=40
40 % 10 = 0
So 131-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H6O5/c11-9(12)7-5-3-1-2-4-6(5)15-8(7)10(13)14/h1-4H,(H,11,12)(H,13,14)
131-76-0Relevant articles and documents
β-Deprotonation by Lithium Di-isopropylamide. Vinyl Carbanions from Oxygen Heterocycles in the Synthesis of Carboxylic Acids in the Benzofuran, Flavone, and Coumarin Series and in the Regiospecific Acylation of 2,6-Dimethylchromone
Costa, Ana M. B. S. R. C. S.,Dean, Francis M.,Jones, Michael A.,Smith, Dennis A.,Varma, Rajender S.
, p. 1224 - 1226 (2007/10/02)
Lithium di-isopropylamide at -70 deg C can remove the α-proton from benzofuran in the absence of activating groups and the β-proton if such groups are present; in flavone and 4-methoxycoumarin β-deprotonation occurs readily and the carbanions are easily carboxylated giving acids not previously accessible, while in 2,6-dimethylchromone β-deprotonation is kinetically favoured allowing 3-acylation to be achieved separately from the conventional acylation at the 2-methyl group.
