131-76-0 Usage
Uses
Used in Organic Synthesis:
1-Benzofuran-2,3-dicarboxylic acid is utilized as a building block in the synthesis of various heterocyclic compounds. Its unique structure allows for the creation of complex organic molecules that can be tailored for specific applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-benzofuran-2,3-dicarboxylic acid is employed as a ligand for coordination chemistry. This role is crucial for the development of new drugs and pharmaceutical agents, as it can influence the properties and effectiveness of the resulting compounds.
Used in Medicinal Chemistry:
1-BENZOFURAN-2,3-DICARBOXYLIC ACID's demonstrated biological activities make it an interesting target for further study in medicinal chemistry. It holds the potential to be developed into new therapeutic agents, particularly given its ability to interact with biological systems in unique ways.
Used in Drug Discovery:
1-Benzofuran-2,3-dicarboxylic acid's potential in drug discovery is underscored by its capacity to contribute to the development of novel pharmaceuticals. Its unique properties and reactivity can lead to the creation of new drug candidates that address unmet medical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 131-76-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 131-76:
(5*1)+(4*3)+(3*1)+(2*7)+(1*6)=40
40 % 10 = 0
So 131-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H6O5/c11-9(12)7-5-3-1-2-4-6(5)15-8(7)10(13)14/h1-4H,(H,11,12)(H,13,14)
131-76-0Relevant academic research and scientific papers
β-Deprotonation by Lithium Di-isopropylamide. Vinyl Carbanions from Oxygen Heterocycles in the Synthesis of Carboxylic Acids in the Benzofuran, Flavone, and Coumarin Series and in the Regiospecific Acylation of 2,6-Dimethylchromone
Costa, Ana M. B. S. R. C. S.,Dean, Francis M.,Jones, Michael A.,Smith, Dennis A.,Varma, Rajender S.
, p. 1224 - 1226 (2007/10/02)
Lithium di-isopropylamide at -70 deg C can remove the α-proton from benzofuran in the absence of activating groups and the β-proton if such groups are present; in flavone and 4-methoxycoumarin β-deprotonation occurs readily and the carbanions are easily carboxylated giving acids not previously accessible, while in 2,6-dimethylchromone β-deprotonation is kinetically favoured allowing 3-acylation to be achieved separately from the conventional acylation at the 2-methyl group.
