131028-55-2

Upstream product

• 131028-54-1 (4-(2-(dimethylamino)ethoxy)phenyl)methanol 
• 50-00-0 formaldehyd 
• 13468-02-5 dimethyl(2-phenoxyethyl)amine 
• 108-95-2 phenol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 38459-72-2 (4-(2-bromoethoxy)phenyl)methan-1-ol 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 

Downstream Products

• 859392-99-7 {2-[4-(3,7-dimethoxy-benzo[4,5]thieno[3,2-b]indol-10-ylmethyl)-phenoxy]-ethyl}-dimethyl-amine 
• 122898-67-3 itopride 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 
• 20059-73-8 4-<2-(dimethylamino)ethoxy>benzylamine 
• 859392-97-5 {2-[4-(7-methoxy-benzo[4,5]thieno[3,2-b]indol-10-ylmethyl)-phenoxy]-ethyl}-dimethyl-amine 

Relevant academic research and scientific papers

Preparation method of itopride hydrochloride

The invention relates to a preparation method of itopride hydrochloride. The preparation method includes: using 2-dimethylaminoethyl chloride hydrochloride and phenol as starting materials for reaction; subjecting the starting materials to etherification, chloromethylation, amino substitution, amidation and salifying to obtain itopride hydrochloride. Chloromethylation promoted by C/CHO is adopted, so that a step of imine reduction is omitted, solid residue generated by a reductant is eliminated, and reaction safety is improved; raw materials used in the method are low in price, sufficient in market supply and easy to purchase; reaction in each step is classic, and the preparation method is safe, easy to control and suitable for industrial production.

Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators

A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERα and ERβ) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong bin